This systematic review found that low-molecular-weight heparin combined with vitamin K antagonist did not differ in safety or efficacy from most treatment strategies; however, rivaroxaban and apixaban were associated with the lowest risk of bleeding.
Omuro and DeAngelis review the clinical management of malignant gliomas, including genetic and environmental risk factors such as cell phones, diagnostic pitfalls, symptom management, specific antitumor therapy, and common complications.
This population-based study using Nationwide Inpatient Sample data reports that the incidence rate of acute traumatic spinal cord injury in the United States remained relatively stable from 1993 to 2012 but, reflecting an increasing population, the total number of cases increased.
This randomized clinical trial compares the effects of whole-body cooling vs usual care on death or disability at 18 to 22 months among infants with hypoxic-ischemic encephalopathy.
Shankaran and coauthors determine if longer duration cooling (120 hours), deeper cooling (32.0°C), or both is superior to cooling to 33.5°C for 72 hours in neonates who are full-term with moderate or severe hypoxic ischemic encephalopathy (HIE).
A 22-year-old woman presented with a 2-month history of fevers and pleuritic chest pain and a 2-day history of cutaneous necroses on her ears, without trauma. Evaluation revealed abnormal coagulation values and a deep vein thrombosis in one leg. What would you do next?
To determine whether antibiotic treatment before and after cholecystectomy, the FRENCH Study group randomized 414 patients between May 2010 and August 2013 with acute calculous cholecystitis to receive either no antibiotic treatment after surgery or amoxicillin plus clavulanic acid for 5 days after surgery. They found that number of infections did not differ between groups.
Robertson and coauthors and the Epo Severe TBI Trial Investigators report the results of a randomized clinical trial on the effect of erythropoietin administration and transfusion threshold on neurological recovery after traumatic brain injury.
This population-based epidemiology study uses Washington State birth and hospitalization data to assess the association between prepregnancy body mass index and severe morbidity or mortality during pregnancy.
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