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  • Effect of an Intensive Lifestyle Intervention on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial

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    JAMA. 2017; 318(7):637-646. doi: 10.1001/jama.2017.10169

    This randomized clinical trial compared the effects of an intensive lifestyle intervention vs standard care on glycemic control and medication reduction among participants with non–insulin-dependent type 2 diabetes.

  • Assessment of Global Kidney Health Care Status

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    JAMA. 2017; 317(18):1864-1881. doi: 10.1001/jama.2017.4046

    This study surveyed international nephrology society leaders, policy makers, and patient representatives to assess regional resources and ability to care for patients with kidney disease.

  • Efficacy and Tolerability of Evolocumab vs Ezetimibe in Patients With Muscle-Related Statin Intolerance: The GAUSS-3 Randomized Clinical Trial

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    JAMA. 2016; 315(15):1580-1590. doi: 10.1001/jama.2016.3608

    This 2-stage randomized clinical trial compared lipid-lowering efficacy of 2 nonstatin therapies, ezetimibe and evolocumab, among patients with uncontrolled low-density lipoprotein cholesterol levels and intolerance to 2 or more statins.

  • Effect of Aleglitazar on Cardiovascular Outcomes After Acute Coronary Syndrome in Patients With Type 2 Diabetes Mellitus: The AleCardio Randomized Clinical Trial

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    JAMA. 2014; 311(15):1515-1525. doi: 10.1001/jama.2014.3321

    Lincoff and coauthors determine whether addition of aleglitazar to standard medical therapy reduces cardiovascular morbidity and mortality among 7226 patients with type 2 diabetes mellitus (T2D) and a recent acute coronary syndrome (ACS).

  • Effect of Tesamorelin on Visceral Fat and Liver Fat in HIV-Infected Patients With Abdominal Fat Accumulation: A Randomized Clinical Trial

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    JAMA. 2014; 312(4):380-389. doi: 10.1001/jama.2014.8334

    Stanley and coauthors conducted a randomized clinical trial among 50 antiretroviral-treated men and women with human immunodefiency virus infection (HIV) and abdominal fat accumulation to investigate the effect of the growth hormone–releasing hormone analog tesamorelin on visceral adipose tissue and liver fat.

  • Platelet Function During Extended Prasugrel and Clopidogrel Therapy for Patients With ACS Treated Without Revascularization: The TRILOGY ACS Platelet Function Substudy

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    JAMA. 2012; 308(17):1785-1794. doi: 10.1001/jama.2012.17312
    Gurbel and coauthors compare the effect of clopidogrel with prasugrel on platelet reactivity among 2564 patients—who were part of a substudy of the TRILOGY ASC trial—whose acute coronary syndromes, which did not include ST-segment elevation, were managed medically. In an editorial, Price discusses implications of the study for clinical practice and future research.
  • Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial

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    JAMA. 2017; 318(16):1550-1560. doi: 10.1001/jama.2017.14972

    This randomized clinical trial compares the effects of whole-body cooling vs usual care on death or disability at 18 to 22 months among infants with hypoxic-ischemic encephalopathy.

  • Nephrologists Question ACP’s Kidney Disease Guidelines

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    JAMA. 2013; 310(22):2387-2388. doi: 10.1001/jama.2013.282671
  • Statin Therapy for Hyperlipidemia

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    JAMA. 2013; 310(11):1184-1185. doi: 10.1001/jama.2013.276734
  • Use of Statins and Gallstone Risk

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    JAMA. 2010; 303(12):1146-1147. doi: 10.1001/jama.2010.321
  • Characteristics of Published Comparative Effectiveness Studies of Medications

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    JAMA. 2010; 303(10):951-958. doi: 10.1001/jama.2010.240
  • Statins, Diet, and Low Cholesterol

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    JAMA. 2006; 295(21):2479-2480. doi: 10.1001/jama.295.21.2479-b
  • Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy: A Meta-analysis

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    JAMA. 2011; 305(24):2556-2564. doi: 10.1001/jama.2011.860
  • Effect of the Use and Timing of Bone Marrow Mononuclear Cell Delivery on Left Ventricular Function After Acute Myocardial Infarction: The TIME Randomized Trial

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    JAMA. 2012; 308(22):2380-2389. doi: 10.1001/jama.2012.28726
    Traverse and coauthors for the Cardiovascular Cell Therapy Research Network report on the effect on left ventricular function of the use and timing of bone marrow mononuclear cell delivery after acute myocardial infarction. In an accompanying Editorial, Marbán and Malliaras discuss the mixed results for bone marrow–derived cell therapy for ischemic heart disease.
  • Effect of Soy Protein Containing Isoflavones on Cognitive Function, Bone Mineral Density, and Plasma Lipids in Postmenopausal Women: A Randomized Controlled Trial

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    JAMA. 2004; 292(1):65-74. doi: 10.1001/jama.292.1.65
  • Implementation of a Sensitive Troponin I Assay and Risk of Recurrent Myocardial Infarction and Death in Patients With Suspected Acute Coronary Syndrome

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    JAMA. 2011; 305(12):1210-1216. doi: 10.1001/jama.2011.338
  • Ten-Year Follow-up After Initiation of Statin Therapy in Children With Familial Hypercholesterolemia

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    JAMA. 2014; 312(10):1055-1057. doi: 10.1001/jama.2014.8892
  • Trends in Prescription Drug Use Among Adults in the United States From 1999-2012

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    JAMA. 2015; 314(17):1818-1830. doi: 10.1001/jama.2015.13766

    This pharmacoepidemiology study uses NHANES data to describe trends in prescription drug use among US adults between 1999 and 2012.

  • High-Dose Statins and the IDEAL Study

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    JAMA. 2006; 295(21):2476-2479. doi: 10.1001/jama.295.21.2476-c
  • Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone

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    JAMA. 2017; 317(7):708-716. doi: 10.1001/jama.2016.21043

    This clinical trial compares the effects of testosterone gel vs placebo for 12 months on noncalcified coronary artery plaque volume in older men with low testosterone.