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  • Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football

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    JAMA. 2017; 318(4):360-370. doi: 10.1001/jama.2017.8334

    This case series investigated the neuropathological and clinical features of deceased football players with chronic traumatic encephalopathy whose brains were donated for research.

  • Assessment of Head Collision Events During the 2014 FIFA World Cup Tournament

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    JAMA. 2017; 317(24):2548-2549. doi: 10.1001/jama.2017.6204

    This study uses video footage observations of all 64 matches of the 2014 FIFA World Cup to assess the incidence, characteristics, and sideline outcome assessments of player head collisions.

  • Concussion and Female Middle School Athletes

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    JAMA. 2014; 312(7):739-740. doi: 10.1001/jama.2014.6668
  • JAMA May 14, 2014

    Figure 1: Smaller Hippocampal Volumes in Collegiate Football Athletes Relative to Healthy Controls

    Total, left hemisphere, and right hemisphere hippocampal volumes for healthy controls (n=25), athletes with no history of concussion (n=25), and athletes with a history of concussion (n=25). Shown in each box plot are the 5th and 95th percentiles (black dots), 10th and 90th percentiles (whiskers), and 25th and 75th percentiles (box top and bottom). The median (solid line) and mean (dotted line) are also shown within each group’s box. Individual volumes for each group are indicated by the symbols to the left of each group’s box plot.
  • JAMA May 14, 2014

    Figure 2: Years of Football Experience Inversely Correlate With Baseline Reaction Time and Left Hemisphere Hippocampal Volume

    Left, total number of years that athletes reported having played football (x-axis) in relation to the Immediate Post-Concussion Assessment and Cognitive Testing composite reaction time score. Forty-four collegiate football players contributed data (n=22 athletes without and n=22 athletes with concussion); the regression line (blue diagonal line) is calculated for all points regardless of concussion history. Right, relationship between years played and left hemisphere hippocampal volume. Forty-eight athletes contributed data for this plot (n=24 athletes without and n=24 athletes with concussion); the regression line (blue diagonal line) is calculated for all points regardless of concussion history. In both graphs, some data markers overlap.
  • Relationship of Collegiate Football Experience and Concussion With Hippocampal Volume and Cognitive Outcomes

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    JAMA. 2014; 311(18):1883-1888. doi: 10.1001/jama.2014.3313

    Singh and coauthors conducted a cross-sectional study among collegiate football players with and without history of concussion and healthy controls to assess the relationships of concussion history and years of football experience with hippocampal volume and cognitive performance in collegiate football athletes.

  • White Matter Integrity in the Brains of Professional Soccer Players Without a Symptomatic Concussion

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    JAMA. 2012; 308(18):1859-1861. doi: 10.1001/jama.2012.13735
  • JAMA November 14, 2012

    Figure 1: Results of the Tract-Based Spatial Statistics (TBSS) Analysis

    The diffusion tensor for each voxel was estimated by the multivariate linear fitting algorithm, and the tensor matrix was diagonalized to obtain 3 pairs of eigenvalues (λ1, λ2, λ3) and eigenvectors. Voxelwise summary parameters included fractional anisotropy, radial diffusivity ([λ2 + λ3]/2), axial diffusivity (λ1), and mean diffusivity (λ1 + λ2 + λ3). Group analyses were performed using whole-brain TBSS for the following measures of diffusivity: fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity. For all analyses, threshold-free cluster enhancement was used to obtain significant differences between groups at P < .05. After accounting for multiple comparisons using the family-wise error rate, the voxels highlighted in red demonstrate significantly increased radial diffusivity and axial diffusivity values for the soccer group compared with swimmers.
  • Study Raises Concerns About “Heading” in Soccer, But Jury Is Still Out on Risks

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    JAMA. 2012; 307(10):1012-1014. doi: 10.1001/jama.2012.231
  • JAMA March 14, 2012

    Figure: Study Raises Concerns About “Heading” in Soccer, But Jury Is Still Out on Risks

    A new study suggests that soccer players may be at risk of impairment because they use the head to intercept and propel the soccer ball.
  • JAMA September 14, 2011

    Figure 1: Transthoracic Echocardiogram of a Study Patient With Typical Bicuspid Aortic Valve

    A, Parasternal short-axis still image demonstrates a typical bicuspid valve (BAV) with a football-shaped systolic opening, right and left cusps forming a large anterior conjoined cusp and commissures at 10 and 4 o’clock (asterisks). B, Numbers indicate location of commissures according to the face of a clock. The study patient’s valve configuration is shown in black. C, Left, parasternal long-axis still image demonstrates anterior conjoined cusp doming in systole. Middle, parasternal long-axis zoomed still image shows leading-edge to leading-edge measurement of the sinuses of valsalva (aortic root) at 49 mm. Right, parasternal long-axis still image 1 intercostal space higher shows measurement of the mid-distal ascending aorta at 46 mm. See interactive videos of the parasternal short- and long-axis echocardiogram.
  • JAMA December 2, 2009

    Figure: Teen Steroid, Supplement Use Targeted

    Chicago-area high school athletes Dean Knieps, Ross Falk, Eric Lee, and Nick DeBenedetti prepare a presentation promoting nutritional techniques as an alternative to steroid use as of an ATLAS event sponsored by the Chicago Bears football team and held at Soldier Field stadium on October 20.
  • Prevalence of Cardiovascular Disease Risk Factors Among National Football League Players

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    JAMA. 2009; 301(20):2111-2119. doi: 10.1001/jama.2009.716
  • JAMA September 19, 2007

    Figure: Researchers Seek Headway in Bringing Science to Sports Concussion Treatment

    While concussions will probably always be a part of football, proper tackling technique, leading with the shoulder instead of the helmet, can help reduce the incidence.
  • Cumulative Effects Associated With Recurrent Concussion in Collegiate Football Players: The NCAA Concussion Study

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    JAMA. 2003; 290(19):2549-2555. doi: 10.1001/jama.290.19.2549
  • Soccer "Sudden Death" Given New Meaning

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    JAMA. 2003; 289(4):413-413. doi: 10.1001/jama.289.4.413
  • JAMA January 23, 2002

    Figure: Football Brain Injuries Draw Increased Scrutiny

    Canadian firm Biokinetics and Associates use raw game footage to analyze head-to-head collisions between football players. Viewing the hit from multiple angles, researchers determine impact vectors, anchoring the calculations to on-field yard markers. (Photo credit: Biokinetics and Associates)
  • Football Brain Injuries Draw Increased Scrutiny

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    JAMA. 2002; 287(4):437-439. doi: 10.1001/jama.287.4.437
  • Neuropsychological Impairment in Amateur Soccer Players

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    JAMA. 1999; 282(10):971-973. doi: 10.1001/jama.282.10.971
  • Traumatic Brain Injury in High School Athletes

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    JAMA. 1999; 282(10):958-963. doi: 10.1001/jama.282.10.958