J.-K. Lee and coauthors performed a systematic review and meta-analysis to determine the association between survival and first-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors vs chemotherapy among patients with advanced non–small cell lung cancer with wild-type EGFR.
This JAMA Insights article explains cell-free circulating tumor DNA and its utility in noninvasive cancer detection and characterization, prediction of treatment response, monitoring of disease relapse, and identification of mechanisms of resistance to targeted therapies.
This phase 1 trial evaluates safety and wound outcomes after transplant of genetically corrected autologous epidermal grafts onto wounds of patients with recessive dystrophic epidermolysis bullosa.
This Genomics and Precision Health article discusses the advantages of chromosomal microarray analysis over G-banded karotyping for evaluating neurodevelopmental disorders in children.
A 43-year-old woman with stage IA endometrial cancer had her tumor screened for DNA mismatch repair proteins and microsatellite instability and had 1 absent immunostain. How do you interpret the test results?
This Viewpoint summarizes new trends in the field of epigenetics and epigenetic epidemiology.
This case series of patients with advanced cancer evaluates the proportion and potential clinical implications of inherited variants detected using DNA sequencing of tumor and normal tissue compared with genetic test results based on current guidelines.
This modeling study uses 3 microsimulation models of a hypothetical cohort to model the benefits, burden, and harms of colorectal cancer screening strategies to inform the 2016 update of US Preventive Services Task Force Recommendation Statement.
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