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  • Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy: A Randomized Clinical Trial

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    JAMA. 2013; 309(13):1359-1367. doi: 10.1001/jama.2013.2813
    To determine whether duloxetine can reduce pain experienced by patients with painful chemotherapy-induced peripheral neuropathy, Smith and coauthors conducted a randomized trial involving 231 patients who received either daily doses of 60 mg of duloxetine or placebo.
  • JAMA April 3, 2013

    Figure 4: Comparison of the Mean Differences in Average Pain Scores Across Duloxetine Chronic Pain Studies

    Duloxetine was compared against placebo in studies involving patients with diabetic neuropathy, Goldstein et al; fibromyalgia, Russell et al; osteoarthritis, Chappell et al; and chemotherapy-induced peripheral neuropathy, the current study, including a breakdown by neurotoxic agent that patients in the current study took.
  • Gabapentin for the Symptomatic Treatment of Painful Neuropathy in Patients With Diabetes Mellitus: A Randomized Controlled Trial

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    JAMA. 1998; 280(21):1831-1836. doi: 10.1001/jama.280.21.1831
  • Association of Type 1 Diabetes vs Type 2 Diabetes Diagnosed During Childhood and Adolescence With Complications During Teenage Years and Young Adulthood

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    JAMA. 2017; 317(8):825-835. doi: 10.1001/jama.2017.0686

    This cohort study uses diabetes registry data to compare rates of complications related to type 1 vs type 2 diabetes among teenagers and young adults diagnosed with diabetes during childhood and adolescence.

  • Acupuncture and Amitriptyline for Pain Due to HIV-Related Peripheral Neuropathy: A Randomized Controlled Trial

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    JAMA. 1998; 280(18):1590-1595. doi: 10.1001/jama.280.18.1590
  • Peripheral and Autonomic Neuropathy in Amyloidosis: A Case Report

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    JAMA. 1963; 186(4):432-434. doi: 10.1001/jama.1963.63710040011018d
  • Repurposing Diflunisal for Familial Amyloid Polyneuropathy: A Randomized Clinical Trial

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    JAMA. 2013; 310(24):2658-2667. doi: 10.1001/jama.2013.283815

    Berk and coauthors conducted an international randomized clinical trial among 130 patients to investigate the effect of diflunisal, a nonsteroidal anti-inflammatory drug, on progression of neurological impairment in familial amyloid polyneuropathy.

  • Effect of a Proposed Trastuzumab Biosimilar Compared With Trastuzumab on Overall Response Rate in Patients With ERBB2 (HER2)–Positive Metastatic Breast Cancer: A Randomized Clinical Trial

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    JAMA. 2017; 317(1):37-47. doi: 10.1001/jama.2016.18305

    This randomized clinical trial compares the overall response rate and safety of a proposed trastuzumab biosimilar vs trastuzumab and a taxane among women with ERBB2 (HER2)–positive metastatic breast cancer.

  • Distal Symmetric Polyneuropathy: A Review

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    JAMA. 2015; 314(20):2172-2181. doi: 10.1001/jama.2015.13611

    This narrative review summarizes current thinking about the diagnosis and treatment of distal symmetric polyneuropathy.

  • Prevalence of Vascular Complications Among Patients With Glucokinase Mutations and Prolonged, Mild Hyperglycemia

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    JAMA. 2014; 311(3):279-286. doi: 10.1001/jama.2013.283980

    Steele and coauthors assess the association between chronic mild hyperglycemia and complication prevalence and severity among 271 participants in the United Kingdom.

  • Efficacy and Safety of Recombinant Human Nerve Growth Factor in Patients With Diabetic Polyneuropathy: A Randomized Controlled Trial

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    JAMA. 2000; 284(17):2215-2221. doi: 10.1001/jama.284.17.2215
  • Effect of Thalidomide on Clinical Remission in Children and Adolescents With Refractory Crohn Disease: A Randomized Clinical Trial

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    JAMA. 2013; 310(20):2164-2173. doi: 10.1001/jama.2013.280777

    In a randomized clinical trial of 56 Italian children with active Crohn disease, Lazzerini and coauthors evaluated the clinical response to thalidomide vs placebo, including measures of clinical remission and adverse events.

  • Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial

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    JAMA. 2017; 317(23):2392-2401. doi: 10.1001/jama.2017.7105

    This randomized clinical trial compares the effect of adding bevacizumab vs cetuximab to standard chemotherapy regimens on overall survival among patients with advanced or metastatic KRAS wild-type colorectal cancer.

  • Fatal Hepatic Necrosis Secondary to Isoniazid Therapy

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    JAMA. 1961; 176(10):877-879. doi: 10.1001/jama.1961.63040230013013b
  • Effect of Tailored Dose-Dense Chemotherapy vs Standard 3-Weekly Adjuvant Chemotherapy on Recurrence-Free Survival Among Women With High-Risk Early Breast Cancer: A Randomized Clinical Trial

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    JAMA. 2016; 316(18):1888-1896. doi: 10.1001/jama.2016.15865

    This randomized clinical trial compares the effects of tailored dose-dense adjuvant chemotherapy vs standard adjuvant chemotherapy on recurrence-free survival in women with high-risk early breast cancer.

  • Retained Needle Fragments in Patients With Diabetic Neuropathy

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    JAMA. 2000; 283(23):3072-3072. doi: 10.1001/jama.283.23.3068h
  • Antiepileptic Drugs for Neuropathic Pain and Fibromyalgia

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    JAMA. 2014; 312(2):182-183. doi: 10.1001/jama.2014.6336
  • Symptomatic Treatment of Painful Neuropathy

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    JAMA. 1998; 280(21):1863-1864. doi: 10.1001/jama.280.21.1863
  • Prescribing Amiodarone: An Evidence-Based Review of Clinical Indications

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    JAMA. 2007; 298(11):1312-1322. doi: 10.1001/jama.298.11.1312
  • The Pathophysiology and Treatment of Glaucoma: A Review

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    JAMA. 2014; 311(18):1901-1911. doi: 10.1001/jama.2014.3192

    In a review of articles published between January 2000 and September 2013, Weinreb and coauthors describe the pathophysiology and glaucoma and recommend early referral of patients with a family history or suspicious optic nerve for ophthalmologic examination.