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  • Tattoo Rash

    Abstract Full Text
    JAMA. 2015; 313(17):1747-1748. doi: 10.1001/jama.2015.0990
  • Endosonography vs Conventional Bronchoscopy for the Diagnosis of Sarcoidosis: The GRANULOMA Randomized Clinical Trial

    Abstract Full Text
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    JAMA. 2013; 309(23):2457-2464. doi: 10.1001/jama.2013.5823
    von Bartheld and coauthors conducted a randomized controlled multicenter trial in 304 patients to compare conventional bronchoscopy with endosonography for the detection of granulomas in patients with suspected pulmonary sarcoidosis.
  • JAMA June 19, 2013

    Figure 1: Study Flowchart

    Enrollment, randomization, and outcome of study participants. Granulomas were defined as granulomas or clusters of epithelioid cells, as can be observed in patients with sarcoidosis. The box “no granulomas” contains all other outcomes. aNo representative biopsy material was present.
  • JAMA January 26, 2011

    Figure 3: T-Cell Signaling and Targets in Sarcoidosis

    T-cell activation may occur via the T-cell receptor (TCR), toll-like receptor (TLR), cytokine or chemokine receptors, leading to signal transduction and activation of transcription factors, which promote gene expression controlling T-cell proliferation, differentiation, apoptosis, anergy, and production of proinflammatory cytokines and chemokines. Sites of action of therapies are shown in blue rectangles (see also Table 2). AMP indicates adenosine monophosphate; AP-1, activator protein 1; ATP, adenosine triphosphate; cAMP, adenosine 3′ 5′ cyclic monophosphate; GTP, guanosine triphosphate; ICAM-1, intercellular adhesion molecule 1; LFA-1, lymphocyte function–associated antigen 1; MHC II, major histocompatibility complex II; MAP3K, mitogen-activated protein kinases; NFAT, nuclear factor of activated T cells; NF-κB, nuclear factor κ B; PDE, phosphodiesterase; PDEI, phosphodiesterase inhibitors; PKC, protein kinase C; TNF, tumor necrosis factor; TNFR, TNF receptor.
  • Sarcoidosis: Clinical Presentation, Immunopathogenesis, and Therapeutics

    Abstract Full Text
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    JAMA. 2011; 305(4):391-399. doi: 10.1001/jama.2011.10
  • Sarcoidosis

    Abstract Full Text
    JAMA. 2011; 305(4):423-423. doi: 10.1001/jama.305.4.423
  • JAMA January 26, 2011

    Figure 2: Proposed Mechanisms of Sarcoid Granuloma Formation

    In a genetically predisposed host, antigen presentation leads to CD4 T-cell activation, downstream clonal proliferation, and elaboration of type 1 helper T cytokines or chemokines. This promotes cellular accumulation and nidus formation, resulting in granuloma. APC indicates antigen-presenting cell; BTNL2, butyrophilin-like protein 2 gene; CCL, chemokine (C-C motif) ligand; CCR, chemokine (C-C motif) receptor; CXCL, chemokine (C-X-C motif) ligand; CXCR, chemokine (C-X-C motif) receptor; MHC II, major histocompatibility complex II; mKatG, Mycobacterium tuberculosis catalase–peroxidase protein; TCR, T-cell receptor; TGF-β, transforming growth factor β; TLR, toll-like receptor; TNF, tumor necrosis factor.
  • JAMA November 1, 2006

    Figure 3: Chest Radiographic Images of Stage 1 and Stage 4 Sarcoidosis

    Left, chest radiographic image of stage 1 sarcoidosis shows bilateral hilar and mediastinal adenopathy without parenchymal lung disease. Right, chest radiographic image of stage 4 sarcoidosis shows diffuse parenchymal lung disease with fibrosis, more prominent in the upper lung zones.
  • A 47-Year-Old Woman With Sarcoidosis

    Abstract Full Text
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    JAMA. 2006; 296(17):2133-2140. doi: 10.1001/jama.296.17.2133
  • Sarcoidosis

    Abstract Full Text
    JAMA. 2006; 296(17):2166-2166. doi: 10.1001/jama.296.17.2166
  • Living With Sarcoidosis

    Abstract Full Text
    JAMA. 2002; 287(10):1350-1350. doi: 10.1001/jama.287.10.1350
  • JAMA September 26, 2017

    Figure 2: County-Level Mortality From Interstitial Lung Disease and Pulmonary Sarcoidosis

    A, Age-standardized mortality rate for both sexes combined in 2014. The color scale is truncated at approximately the first and 99th percentiles as indicated by the range given in the color scale. B, Relative change in the age-standardized mortality rate for both sexes combined between 1980 and 2014. The color scale is truncated at approximately the 99th percentile but not at the first percentile, to avoid combining counties where the mortality rate increased with counties where the mortality rate decreased in the same group. C, Age-standardized mortality rate in 1980, 1990, 2000, and 2014. The bottom border, middle line, and top border of the boxes indicate the 25th, 50th, and 75th percentiles, respectively, across all counties; whiskers, the full range across counties; and circles, the national-level rate.
  • JAMA January 26, 2011

    Figure: Sarcoidosis

  • Early Diagnosis of Sarcoidosis—ReplyEarly Diagnosis of Sarcoidosis—Reply

    Abstract Full Text
    JAMA. 2003; 290(11):1454-1454. doi: 10.1001/jama.290.11.1454-a
  • Comparison of Methods to Diagnose Sarcoidosis

    Abstract Full Text
    JAMA. 2013; 310(15):1624-1624. doi: 10.1001/jama.2013.277314
  • Comparison of Methods to Diagnose Sarcoidosis

    Abstract Full Text
    JAMA. 2013; 310(15):1624-1625. doi: 10.1001/jama.2013.277317
  • Comparison of Methods to Diagnose Sarcoidosis—Reply

    Abstract Full Text
    JAMA. 2013; 310(15):1625-1626. doi: 10.1001/jama.2013.277322