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  • JAMA June 5, 2013

    Figure 2: Distribution of Leakage of Retinal Vessels in 7 Participants and Composite Fundus Image Showing Leakage in 1 Participant

    Although none of the participants showed leakage in the nasal-superior periphery, all showed leakages in the temporal periphery.
  • JAMA June 5, 2013

    Figure 1: Fluorescein Angiography Showing Leakage of Peripheral Retinal Vessels in 1 Participant at High Altitude

    At baseline altitude (left) peripheral retinal vasculature shows no fluorescein leakage while at high altitude (center) marked leakage is visible in the wide temporal periphery. Findings completely reversed after return to baseline altitude (right). This participant had no symptoms of acute mountain sickness (Lake Louise score: 0; acute mountain sickness cerebral score: 0.18).
  • Retinal Vessel Leakage at High Altitude

    Abstract Full Text
    free access
    JAMA. 2013; 309(21):2210-2212. doi: 10.1001/jama.2013.5550
  • Retinopathy

    Abstract Full Text
    JAMA. 2007; 298(8):944-944. doi: 10.1001/jama.298.8.944
  • JAMA December 6, 2000

    Figure 2: Retinal and Hepatic Characteristics of Fabry Disease

    A, Retinal image showing tortuous retinal blood vessels. B, Liver biopsy showing lamellar storage material in the cytoplasm of a Kupffer cell. The cell is adjacent to a capillary in which a red blood cell can be seen (original magnification ×17,000).
  • JAMA May 24, 2006

    Figure 1: Macula Lutea and Ocular Structures With Age-Related Macular Degeneration (AMD)

    A, Fundus photograph of normal retina.The macula is the central part of the retina delimited by the superior temporal and inferior temporal retinal vascular arcades. The fovea is about the size of the optic nerve (diameter, 1500 μm) and is centered on the foveola (diameter, 350 μm). The foveola is the thinnest part of the retina. It is devoid of ganglion cells and is responsible for the most acute detailed vision. B, Cross section of normal retina, choroid, and sclera. A photon of light must penetrate all of the layers of the retina before being absorbed and converted into a neural signal by the photoreceptor outer segments. This retinal transparency results from the structured organization and orientation of the retinal cell bodies and processes. The retinal photoreceptors and retinal pigment epithelium (RPE) are metabolically active cells that depend on the choroidal vasculature to supply oxygen and nutrients and remove metabolic waste. C, Dry AMD or nonneovascular AMD is characterized by nodular, hard drusen, with sharp edges, diffuse soft drusen, and RPE hyperplasia and hyperpigmentation. Histologically, drusenoid material is found between the RPE and the RPE basement membrane (basal laminar deposits) and/or between the RPE basement membrane and the collagenous layer of Bruch membrane (basal linear deposits). The risk for progression to wet or neovascular AMD increases with increasing number and size of drusen and the presence of RPE pigmentary abnormalities. Wet AMD or neovascular AMD is characterized by the intrusion of abnormal new vessels from the choroid into the subretinal (type 2) and/or sub-RPE (type 1) space. In some cases, neovascularization may originate from the retinal vessels (not shown), with or without a choroidal component. Choroidal neovascularization often exudes fluid and/or hemorrhage into the subretinal and/or sub-RPE space.
  • What Does This Retina Examination Show?

    Abstract Full Text
    JAMA. 2015; 314(23):2555-2556. doi: 10.1001/jama.2015.9162

    A 50-year-old man reported experiencing blurry vision for 5 months. He has a BMI of 30.6 and blood pressure of 160/102 mm Hg. Dilated retinal examination showed arteriolar narrowing, microaneurysms, intraretinal hemorrhaging, and cotton-wool spots. What would you do next?

  • Retinopathy

    Abstract Full Text
    JAMA. 2005; 293(1):128-128. doi: 10.1001/jama.293.1.128
  • JAMA November 25, 2009

    Figure 3: Fundus Photograph of Vitreous Hemorrhage

    Superiorly, vitreous hemorrhage is completely obscuring retinal details. Inferiorly, some hazy retinal details (including vessels) can be observed through the vitreous hemorrhage.
  • Sudden Vision Loss

    Abstract Full Text
    free access
    JAMA. 2017; 318(6):584-584. doi: 10.1001/jama.2017.7950
  • Scientists Take Aim at Angiogenesis to Treat Degenerative Eye Diseases

    Abstract Full Text
    JAMA. 2004; 291(11):1309-1310. doi: 10.1001/jama.291.11.1309
  • Vision Researchers Seek to Be Armed Against Damaging ARMD

    Abstract Full Text
    JAMA. 1999; 282(18):1711-1712. doi: 10.1001/jama.282.18.1711-JMN1110-3-1
  • Postprocedural Blue Toes

    Abstract Full Text
    JAMA. 2016; 315(13):1396-1397. doi: 10.1001/jama.2016.1810

    A man in his 70s with a history of recent CABG surgery presented with blue, tender plantar macules on several toes and red, tender macules on his hands. Laboratory findings included a BUN level of 70 mg/dL, serum creatinine level of 6.1 mg/dL, and peripheral eosinophilia. What would you do next?

  • VEGF Inhibitors for AMD and Diabetic Macular Edema

    Abstract Full Text
    JAMA. 2015; 314(20):2184-2185. doi: 10.1001/jama.2015.15427

    This Medical Letter review summarizes several vascular endothelial growth factor inhibitors used to treat age-related macular degeneration and diabetic macular edema.

  • Regenerative Medicine

    Abstract Full Text
    JAMA. 2015; 313(14):1413-1414. doi: 10.1001/jama.2015.1492

    This Viewpoint describes how regenerative medicine through advances in cell biology, biomaterial science, and biological molecule discovery can replace or regenerate human cells, tissues, and organs harmed by disease or injury.

  • Macular Degeneration

    Abstract Full Text
    JAMA. 2008; 299(11):1252-1252. doi: 10.1001/jama.299.11.1252-d
  • The Resistance of Various Nerve-Cells to Anemia

    Abstract Full Text
    JAMA. 2013; 310(23):2570-2570. doi: 10.1001/jama.2013.5471
  • Retinoblastoma Therapy Delivers Power of Chemotherapy With Surgical Precision

    Abstract Full Text
    JAMA. 2011; 305(22):2276-2278. doi: 10.1001/jama.2011.778
  • Eye Emergencies

    Abstract Full Text
    free access
    JAMA. 2017; 318(7):676-676. doi: 10.1001/jama.2017.9899
  • The Retinal Vessels: Comparative Ophthalmoscopic and Histologic Studies on Healthy and Diseased Eyes

    Abstract Full Text
    JAMA. 1965; 192(5):427-427. doi: 10.1001/jama.1965.03080180085045