This randomized clinical trial compares the efficacy of 4 oral combination analgesics among adult patients treated for moderate to severe acute extremity pain at 2 urban emergency departments in the United States.
A comprehensive urine drug screen for a 50-year-old woman taking daily methadone, immediate-release morphine, gabapentin, duloxetine, and celecoxib for pain was positive for methadone and morphine but also codeine and hydromorphone. How do you interpret the results?
This Viewpoint discusses how physicians’ choice of words can amplify patients’ symptoms and distress and suggests approaches to communication in common situations that could reduce iatrogenic nocebo effects.
This report describes findings from 3 randomized clinical trials designed to compare the effects of a standardized exercise program with vs without radiofrequency denervation for treatment of chronic low back pain.
This Viewpoint advocates for reducing opioid misuse among primary care patients with chronic pain through a comprehensive approach emphasizing shared decision making, nonpharmacological treatments, nonopioid therapy, and a focus on functional improvement rather than pain elimination.
This Clinical Evidence Synopsis summarizes a Cochrane review of clinical trials comparing nonsteroidal anti-inflammatory drugs (NSAIDs) with other drug treatments, nondrug treatments, or placebo in patients with chronic low back pain.
This study uses insurance claims and HCAHPS data to investigate correlations between measures of pain and patient satisfaction after hospital discharge and postoperative opioid prescriptions.
This randomized trial compares the effects of intra-articular triamcinolone vs saline injected every 3 months for 2 years on changes in cartilage volume and pain in older adult patients with knee osteoarthritis.
This retrospective study compared risk of death among Medicaid patients in Tennessee initiating long-acting opioid therapy for chronic noncancer pain with patients taking anticonvulsants or cyclic antidepressants.
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