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  • JAMA December 21, 2011

    Figure 1: Cytokine Secretion in Stimulated Splenocytes

    Spleens were harvested from patients who died of sepsis (n = 24-26) or nonsepsis etiologies (n = 20-21). Cells were dissociated and washed and viability determined by trypan blue exclusion. Viable splenocytes (1 × 107) were stimulated with lipopolysaccharide or anti-CD3/anti-CD28 antibody. Supernatants were harvested at 5 and 22 hours and tumor necrosis factor (TNF), interferon γ (IFN-γ), and interleukins (IL) 6 and 10 were measured by enzyme-linked immunosorbent assay. There was a marked decrease in cytokine secretion in sepsis patients vs nonsepsis controls. Data were analyzed by 2-tailed nonparametric t test (Mann-Whitney U test). Each data marker represents an individual patient. Horizontal lines represent mean values. P <.001 for all plots, except P <.01 for TNF with lipopolysaccharide stimulation at 22 hours.
  • Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

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    JAMA. 2011; 306(23):2594-2605. doi: 10.1001/jama.2011.1829
  • Effect of Azithromycin on Pulmonary Function in Patients With Cystic Fibrosis Uninfected With Pseudomonas aeruginosa : A Randomized Controlled Trial

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    JAMA. 2010; 303(17):1707-1715. doi: 10.1001/jama.2010.563
  • Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis: The ACCESS Randomized Trial

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    JAMA. 2013; 309(11):1154-1162. doi: 10.1001/jama.2013.2194
    In a randomized, double-blind, placebo-controlled, multinational phase 3 trial in 197 intensive care units (1961 patients), Opal and coauthors explored whether eritoran, a TLR4 antagonist, significantly reduced sepsis-induced mortality.
  • Immunogenicity of 2 Serogroup B Outer-Membrane Protein Meningococcal Vaccines: A Randomized Controlled Trial in Chile

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    JAMA. 1999; 281(16):1520-1527. doi: 10.1001/jama.281.16.1520
  • Association of TNF2 , a TNF-α Promoter Polymorphism, With Septic Shock Susceptibility and Mortality: A Multicenter Study

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    JAMA. 1999; 282(6):561-568. doi: 10.1001/jama.282.6.561
  • Postdiarrheal Shiga Toxin–Mediated Hemolytic Uremic Syndrome

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    JAMA. 2003; 290(10):1379-1381. doi: 10.1001/jama.290.10.1379
  • Effect of Prolonged Methylprednisolone Therapy in Unresolving Acute Respiratory Distress Syndrome: A Randomized Controlled Trial

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    JAMA. 1998; 280(2):159-165. doi: 10.1001/jama.280.2.159
  • Respiratory Infections With Pseudomonas aeruginosa in Children With Cystic Fibrosis: Early Detection by Serology and Assessment of Risk Factors

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    JAMA. 2002; 287(22):2958-2967. doi: 10.1001/jama.287.22.2958
  • Diagnosis of Intra-amniotic Infection by Proteomic Profiling and Identification of Novel Biomarkers

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    JAMA. 2004; 292(4):462-469. doi: 10.1001/jama.292.4.462
  • A Polymorphism in the Cyclooxygenase 2 Gene as an Inherited Protective Factor Against Myocardial Infarction and Stroke

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    JAMA. 2004; 291(18):2221-2228. doi: 10.1001/jama.291.18.2221
  • E5 Murine Monoclonal Antiendotoxin Antibody in Gram-Negative Sepsis: A Randomized Controlled Trial

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    JAMA. 2000; 283(13):1723-1730. doi: 10.1001/jama.283.13.1723
  • Bacterial Endotoxin (Lipopolysaccharide) as a Cause of Erythema Multiforme

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    JAMA. 1980; 243(1):58-60. doi: 10.1001/jama.1980.03300270046029
  • Antimicrobial Resistance

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    JAMA. 2016; 316(11):1193-1204. doi: 10.1001/jama.2016.11764

    In this Special Communication, Anthony Fauci and colleagues review ecological factors contributing to, mechanisms of, and novel strategies to manage antimicrobial resistance.

  • Novel Programs and Discoveries Aim to Combat Antibiotic Resistance

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    JAMA. 2015; 313(24):2411-2413. doi: 10.1001/jama.2015.4738

    In the wake of increasing antimicrobial resistance threats, this article discusses some recent government initiatives and efforts by scientists, physicians, and public health officials to combat drug-resistant bacteria.

  • JAMA April 21, 2015

    Figure 1: Longitudinal Evaluation of Gene Marking in Blood Cells After Gene Therapy

    A, Gene marking in peripheral blood cells over time after gene therapy in patients 1 to 7, as expressed by vector copy number per peripheral blood mononuclear cell (PBMC) and measured by quantitative polymerase chain reaction. B, Gene marking in various blood cell subsets in each patient, expressed as vector copy number per cell in CD3+ T cells, CD56+ natural killer cells, CD19+ B cells, CD15+ neutrophils, and CD14+ monocytes.
  • Traveler’s Diarrhea: A Clinical Review

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    JAMA. 2015; 313(1):71-80. doi: 10.1001/jama.2014.17006

    This Review examines the current state of knowledge on the etiology, risk factors, prevention, and management of traveler’s diarrhea.

  • Genetic Variants Associated With Susceptibility to Helicobacter pylori— Reply

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    JAMA. 2013; 310(9):976-977. doi: 10.1001/jama.2013.194772
  • Compliance With Live, Oral Ty21a Typhoid Vaccine

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    JAMA. 1992; 267(8):1074-1074. doi: 10.1001/jama.1992.03480080044022
  • Identification of Genetic Loci Associated With Helicobacter pylori Serologic Status

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    JAMA. 2013; 309(18):1912-1920. doi: 10.1001/jama.2013.4350
    To identify genetic loci associated with H pylori seroprevalence and determine the pathophysiological role of these loci, Mayerle and coauthors performed a metaanalysis of genome-wide association studies conducted in population-based cohorts, with subsequent whole-blood transcriptome analyses conducted in independent cohorts from the same populations. El-Omar provides comment in the related Editorial.