This JAMA Guide to Statistics and Methods reviews the concepts underlying mendelian randomization and provides examples of its application to clinical trial design.
This mendelian randomization analysis of individual-participant data estimated the association between changes in levels of low-density lipoprotein cholesterol (and other lipoproteins) and risk of cardiovascular events due to CETP variants, alone and in combination with HMGCR variants.
This Viewpoint discusses variances in cardiovascular prevention guidelines from the United States, Europe, and Canada and the debate surrounding low-density lipoprotein levels as the primary focus.
This Evidence Report and systematic review to support a 2017 US Preventive Services Task Force Recommendation Statement summarizes current evidence on benefits and harms of behavioral counseling for primary prevention of cardiovascular disease (CVD) in adults without known CVD risk factors.
This randomized clinical trial compares the effects of evolocumab vs placebo on change in percent atheroma volume among adult patients with angiographic coronary disease despite treatment with statins.
This Viewpoint discusses the role of implementation and translational science and digital platforms for improving population cardiovascular risk and advancing precision treatments in an era of intensive statin therapy and PCSK9 inhibitors.
This meta-analysis of genetic association studies summarizes associations between molecular targets of lipid-lowering therapy and risk of type 2 diabetes and coronary artery disease.
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