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  • Interventions for Rosacea

    Abstract Full Text
    JAMA. 2015; 314(22):2403-2404. doi: 10.1001/jama.2015.15287

    This Clinical Evidence Synopsis summarizes a Cochrane review on the efficacy of interventions for rosacea.

  • Can You Hear Me Now?

    Abstract Full Text
    JAMA. 2015; 314(17):1789-1789. doi: 10.1001/jama.2015.14007
  • Acupuncture for Chronic Knee Pain: A Randomized Clinical Trial

    Abstract Full Text
    free access
    JAMA. 2014; 312(13):1313-1322. doi: 10.1001/jama.2014.12660

    This randomized trial reports measures of pain and function among patients with chronic knee pain who underwent needle acupuncture, laser acupuncture, or sham or no acupuncture.

  • JAMA October 1, 2014

    Figure: Flow of Participants Through the Trial

    A participant was deemed lost to follow-up if all of the outcomes that were intended to be measured were missing at that follow-up. Participants lost to follow-up at 12 weeks were not followed up at 1 year, with single exceptions in each of the control and laser acupuncture groups.aOne rejoined at 1 year after having been lost to follow-up at 12 weeks.
  • JAMA June 11, 2014

    Figure: Diabetic Retinopathy Clinical Research Network ( Trial Results and Diabetic Macular Edema

    A, Intravitreal ranibizumab for diabetic macular edema with prompt versus deferred laser treatment. Visual acuity change from baseline among 4 groups randomized to receive prompt focal/grid laser plus a sham intravitreal injection, prompt laser plus intravitreal ranibizumab, deferred laser (for at least 24 weeks) plus intravitreal ranibizumab, or prompt laser plus intravitreal corticosteroids through 2 years with a 3-year comparison of the 2 ranibizumab groups. B, Fundus photograph of case with diabetic macular edema. Circle indicates lipid, ie, hard exudates, near the center of the macula.
  • JAMA January 6, 2010

    Figure: Optogenetics Illuminates Brain Function

    Blue laser light delivered deep into the brain of a mouse that has been genetically altered to produce light-sensitive proteins in select neurons can influence the animal's behavior.
  • Scientists Get 3-D View of Living Cells

    Abstract Full Text
    JAMA. 2007; 298(14):1630-1630. doi: 10.1001/jama.298.14.1630
  • Management of Diabetic Retinopathy: A Systematic Review

    Abstract Full Text
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    JAMA. 2007; 298(8):902-916. doi: 10.1001/jama.298.8.902
  • JAMA April 20, 2005

    Figure 2: MALDI-TOF Mass Spectrometry of Apo C-I–Enriched HDL and Normal HDL

    Apo indicates apolipoprotein; MALDI-TOF, matrix-assisted laser desorption/ionization time-of-flight; and HDL, high-density lipoprotein. Apo C-I–enriched HDL (A and B) and normal HDL (C and D) were isolated from plasma of a group 0 infant (A and C) and a group 3 infant (B and D) and prepared for MALDI-TOF mass spectrometry (see “Methods” section).
  • JAMA July 28, 2004

    Figure 1: SELDI-TOF Mass Spectrometry Analysis of Amniotic Fluid in Control and Group B Streptococcus–Infected Samples

    SELDI-TOF indicates surface-enhanced laser desorption/ionization time-of-flight. Group B Streptococcus infection–induced differential protein expression in nonhuman primate (A) and human (B) amniotic fluid samples. SELDI-TOF-mass spectrometry spectrum of amniotic fluid extracts bound to chemically defined Normal Phase Protein chip arrays. Spectrum from 2.5 to 15 kDa collected at 235 laser intensity. Detailed spectra show increased expression of the 3.5-kDa and 10.8-kDa peaks between control and infected. Arrows indicate the unique peaks represented by polypeptides overexpressed in infection.
  • JAMA July 28, 2004

    Figure 2: Detection of Intra-amniotic Infection Resulting From Different Microorganisms

    Surface-enhanced laser desorption/ionization time-of-flight analysis of nonhuman primate amniotic fluid before and after infection using Normal Phase Protein chip arrays. The 10.8-kDa candidate biomarker is detected in amniotic fluid infected with Mycoplasma hominis and Ureaplasma parvum. Detection in group B Streptococcus is shown in Figure 1.
  • Treatment of Acne Vulgaris With a Pulsed Dye Laser: A Randomized Controlled Trial

    Abstract Full Text
    free access
    JAMA. 2004; 291(23):2834-2839. doi: 10.1001/jama.291.23.2834
  • Future Bright for Light as Dermatologic Tool

    Abstract Full Text
    JAMA. 2002; 287(14):1788-1792. doi: 10.1001/jama.287.14.1788-JMN0410-2-1
  • JAMA April 3, 2002

    Figure 2: Confocal Laser Scanning Micrographs of the Chinchilla Middle-Ear Mucosa Following Transbullar Inoculation With Haemophilus Influenzae

    Unfixed specimens were obtained under general anesthesia, placed in buffer, and shipped via overnight courier from the Center for Genomic Sciences to the Center for Bioengineering for imaging. Specimens were stained using the Live/Dead BacLight bacterial viability kit (Molecular Probes, Eugene, Ore), which uses the 2 dyes, SYTO 9 (green) and propidium iodide (red). Green indicates uncompromised bacterial cell membranes (ie, live cells); red indicates dead cells and is also taken up by the host cell nuclei. Panel A shows an early-stage biofilm, panels B and C show mature biofilms with characteristic tower structure (arrowheads); and panel D shows a biofilm at 21 days after inoculation. Scale: nuclei are approximately 5 µm in diameter; mucosal cells, approximately 15 µm in diameter.
  • JAMA November 14, 2001

    Figure 2: Laser Capture Microdissection

    A, Tissue sections are processed and placed on a microscope slide under a thin, transparent thermoplastic film, which is attached to a movable cap. Visualizing the tissue microscopically, a short-duration, focused pulse from an infrared carbon-dioxide laser is used to activate and melt the film to selectively adhere cells within targeted areas of interest. B, When the cap is lifted, the film, with selected cells still bound, is removed from the tissue section for further processing to retrieve cellular materials (eg, DNA, RNA, proteins).
  • JAMA February 28, 2001

    Figure 1: Isolate of Tropheryma whippelii

    Slow-Marseille isolate of Tropheryma whippelii growing in human fibroblast cell line, as resolved by immunofluorescence and using laser confocal fluorescence microscopy (original magnification ×1000).

    Abstract Full Text
    JAMA. 2000; 283(16):2095-2095. doi: 10.1001/jama.283.16.2095-JMN0426-3-2
  • New Laser Target: Otitis Media

    Abstract Full Text
    JAMA. 1999; 282(19):1803-1803. doi: 10.1001/jama.282.19.1803-JMN1117-2-1
  • JAMA April 14, 1999

    Figure: High-Tech Angina Relief Explored in Treatment Trials

    The coaxial catheter with a laser, within the left ventricle, creates channels in the ischemic region of a heart to relieve angina. (Credit: CardioGenesis Corp)