Showing 1 – 20 of 202
Relevance | Newest | Oldest |
  • Banning Electrical Shock Devices

    Abstract Full Text
    JAMA. 2016; 315(21):2268-2268. doi: 10.1001/jama.2016.6560
  • Copy Number Variations and Cognitive Phenotypes in Unselected Populations

    Abstract Full Text
    free access is active quiz
    JAMA. 2015; 313(20):2044-2054. doi: 10.1001/jama.2015.4845

    This population-based study investigated the association of copy number variance and cognitive phenotypes and educational attainment and intellectual disability among individuals whose genetic samples are recorded in the Estonian Genome Center, the University of Tartu, 5% of the population, with the general Estonian population.

  • Cognitive Phenotypes and Genomic Copy Number Variations

    Abstract Full Text
    JAMA. 2015; 313(20):2029-2030. doi: 10.1001/jama.2015.4846
  • In Vitro Fertilization and Risk of Autistic Disorder and Mental Retardation

    Abstract Full Text
    JAMA. 2013; 310(1):42-43. doi: 10.1001/jama.2013.7223
  • Autism and Mental Retardation Among Offspring Born After In Vitro Fertilization

    Abstract Full Text
    free access
    JAMA. 2013; 310(1):75-84. doi: 10.1001/jama.2013.7222

    Sandin and coauthors examined the association between birth after in vitro fertilization (IVF) and neurodevelopmental outcomes in a population-based prospective cohort study involving more than 2.5 million Swedish children born between 1982 and 2007. In an Editorial, Cedars discusses the need for continued study of the relationship between IVF procedures and neurodevelopmental outcomes.

  • Sequencing Inches Closer to the Clinic: Neonatal, Intellectual Disorders Identified

    Abstract Full Text
    JAMA. 2012; 308(19):1961-1962. doi: 10.1001/jama.2012.14629
  • JAMA November 9, 2011

    Figure 3: Dorsolateral (DL-PFC) and Mesial Prefrontal Cortex (M-PFC) Neuron Counts in Autism vs Control Group Cases

    Error bars indicate 95% CIs. For between-group comparisons, statistical tests were as follows: P = .003 for panel A, P = .009 for panel B, and P = .002 for panel C. Autistic case with lowest neuron count value in panels A and C had a seizure disorder, adverse perinatal medical conditions, and intellectual disability.
  • JAMA November 9, 2011

    Figure 4: Prefrontal Neuron Counts as a Function of Percent Difference of Brain Weight From Age-Based Norms

    Plot of total prefrontal neuron counts as a function of percent difference of brain weight from age-based norms for each study case. In control cases, the correlation between counts and % difference was r = 0.949 (P = .004); the best-fit line for this is shown. Six of the 7 autistic children had neuron counts that met or exceeded the control line, indicating that they had equal to or more neurons than predicted from their large brain weight. An autistic boy with a seizure disorder was an exception in that he had fewer neurons than would be predicted for his brain weight (closed circle within circle). Three autistic cases without intellectual disability shown with extra open circle; each also met or exceeded the control regression line. The largest control brain from among approximately 11 000 brains (see Redcay and Courchesne) had a percent difference from age-based norms of 22% where the solid best-fit line ends. The dashed line is an extrapolation because typical brains do not commonly achieve such size.
  • JAMA September 21, 2011

    Figure 1: Flow of Participants Through the Trial

    aGate A exclusions are more than 421 because some patients had more than 1 reason for their exclusion.bOf these, 13 had diagnosis of pervasive developmental disorder or mental retardation; 5 had pediatric autoimmune neruropsychiatric disorders associated with streptococcal infections. CBT indicates cognitive behavior theratpy; CY-BOCS, Children's Yale-Brown Obsessive Compulsive Scale; OCD; obsessive-compulsive disorder; SRI, serotonin reuptake inhibitor.
  • Aging Adults With Intellectual Disabilities

    Abstract Full Text
    JAMA. 2010; 304(1):91-92. doi: 10.1001/jama.2010.906
  • JAMA December 23, 2009

    Figure: Fragile X Therapy Probed

    A drug for fragile X syndrome, which is caused by changes in the fragile X mental retardation gene (FMR1), is entering clinical trials.
  • Genes and Intellectual Disability

    Abstract Full Text
    JAMA. 2009; 301(21):2202-2202. doi: 10.1001/jama.2009.757
  • JAMA November 26, 2008

    Figure: Expression of the FMR1 Gene and Associated Clinical Disorders

    Expression of the fragile X mental retardation 1 (FMR1) gene depends on the length of the CGG repeat. Premutation alleles result in elevated mRNA levels (increased RNA synthesis). Within this CGG repeat range, the expanded CGG repeat in FMR1 mRNA partially blocks translation to an extent that depends on the size of the repeat. Full mutation alleles are generally hypermethylated and silenced, thus producing little or no mRNA or protein. The excess premutation mRNA is now believed to give rise to the premutation-specific disorders, fragile X–associated tremor/ataxia syndrome and primary ovarian insufficiency, and may also contribute to developmental delays, attention-deficit/hyperactivity disorder, or autism spectrum disorders in some children with the premutation. By contrast, fragile X syndrome is caused by the absence of the FMR1 mRNA and protein (FMRP). In the upper portion of the premutation CGG repeat range, mRNA toxicity and reduced FMRP levels may both contribute to clinical involvement. UTR indicates 5′ untranslated region.
  • Intellectual Disability

    Abstract Full Text
    JAMA. 2008; 299(11):1252-1252. doi: 10.1001/jama.299.11.1252-a
  • JAMA July 18, 2007

    Figure: New Manual Helps Assess Mental Health of People With Intellectual Disabilities

    A new mental health diagnostic manual will help clinicians apply the DSM-IV criteria to individuals who have intellectual disability.
  • New Manual Helps Assess Mental Health of People With Intellectual Disabilities

    Abstract Full Text
    JAMA. 2007; 298(3):275-276. doi: 10.1001/jama.298.3.275
  • Mental Retardation Clue

    Abstract Full Text
    JAMA. 2007; 297(21):2339-2339. doi: 10.1001/jama.297.21.2339-c
  • Psychopathology in Young People With Intellectual Disability

    Abstract Full Text
    free access
    JAMA. 2006; 296(16):1981-1989. doi: 10.1001/jama.296.16.1981
  • Putting Mental Retardation and Mental Illness on Health Care Professionals' Radar Screen

    Abstract Full Text
    JAMA. 2002; 288(4):433-435. doi: 10.1001/jama.288.4.433