A 79-year-old man with a history of hypertension and stroke presented to the emergency department unresponsive with an undetectable temperature. Blood pressure was 85/55 mm Hg; pulse oximetry was 100% on ambient air. An ECG revealed sinus bradycardia with Osborn waves and attenuated P waves. What would you do next?
Shankaran and coauthors determine if longer duration cooling (120 hours), deeper cooling (32.0°C), or both is superior to cooling to 33.5°C for 72 hours in neonates who are full-term with moderate or severe hypoxic ischemic encephalopathy (HIE).
Kim and coauthors report on the effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest. In an accompanying Editorial, Granger and Becker discuss the use of prehospital and immediate cardiac therapies.
To test whether induced hypothermia improves outcome in severe bacterial meningitis, Mourvillier
and coauthors assessed 130 patients in 49 intensive care units in France and 98 comatose adults
(defined as having a Glasgow Coma Scale score of ≤8 for <12 hours) with community-acquired
bacterial meningitis who received either cold saline or usual care.
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