Porsteinsson and colleagues evaluate the efficacy of citalopram for agitation in patients with Alzheimer disease in a randomized controlled trial comprising 186 patients with probable Alzheimer disease and clinically significant agitation from 8 US and Canadian centers, August 2009-January 2013.
This randomized clinical trial compares the effects of sertraline vs placebo on depressive symptoms in patients with stage 3, 4, or 5 non–dialysis-dependent chronic kidney disease and major depressive disorder.
Vora and coauthors investigated whether organ transplantation was the source of rabies virus
exposure in a kidney recipient who died 18 months after transplantation. They then evaluated for and
prevented rabies in other transplant recipients from the same donor. In an Editorial, Kaul discusses
the implications for improving the safety of solid organ transplantation.
This randomized trial investigated whether oral hydration with dilute apple juice followed by preferred fluids was noninferior to administration of electrolyte maintenance solution for treatment of children presenting to the emergency department with mild gastroenteritis and minimal dehydration.
Sacks and coauthors identify the reasons that US Food and Drug Administration (FDA) marketing approval for new drugs was delayed or denied in drug applications for new molecular entities first submitted to the FDA between 2000 and 2012.
Lipsitz discusses the case of a 91-year-old woman with difficult-to-control hypertension and the presentation, pathophysiology, and optimal treatment of hypertension among elderly persons.
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