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  • Association of Atrial Tissue Fibrosis Identified by Delayed Enhancement MRI and Atrial Fibrillation Catheter Ablation: The DECAAF Study

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    JAMA. 2014; 311(5):498-506. doi: 10.1001/jama.2014.3

    Marrouche and coauthors report the results of the DECAAF study, which was a multicenter assessment of the association of atrial tissue fibrosis identified by delayed enhancement magnetic resonance imaging (MRI) and catheter ablation outcomes in patients with atrial fibrillation.

  • Efficacy and Tolerability of Evolocumab vs Ezetimibe in Patients With Muscle-Related Statin Intolerance: The GAUSS-3 Randomized Clinical Trial

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    JAMA. 2016; 315(15):1580-1590. doi: 10.1001/jama.2016.3608

    This 2-stage randomized clinical trial compared lipid-lowering efficacy of 2 nonstatin therapies, ezetimibe and evolocumab, among patients with uncontrolled low-density lipoprotein cholesterol levels and intolerance to 2 or more statins.

  • Platelet Function During Extended Prasugrel and Clopidogrel Therapy for Patients With ACS Treated Without Revascularization: The TRILOGY ACS Platelet Function Substudy

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    JAMA. 2012; 308(17):1785-1794. doi: 10.1001/jama.2012.17312
    Gurbel and coauthors compare the effect of clopidogrel with prasugrel on platelet reactivity among 2564 patients—who were part of a substudy of the TRILOGY ASC trial—whose acute coronary syndromes, which did not include ST-segment elevation, were managed medically. In an editorial, Price discusses implications of the study for clinical practice and future research.
  • Association of High-Sensitivity Cardiac Troponin I Concentration With Cardiac Outcomes in Patients With Suspected Acute Coronary Syndrome

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    JAMA. 2017; doi: 10.1001/jama.2017.17488

    This systematic review evaluates the performance of a cardiac troponin I threshold of 5 ng/L at presentation as a risk stratification tool in patients with suspected acute coronary syndrome.

  • Statin Therapy for Hyperlipidemia

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    JAMA. 2013; 310(11):1184-1185. doi: 10.1001/jama.2013.276734
  • Statins, Diet, and Low Cholesterol

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    JAMA. 2006; 295(21):2479-2480. doi: 10.1001/jama.295.21.2479-b
  • Association Between Long-Lasting Intravitreous Fluocinolone Acetonide Implant vs Systemic Anti-inflammatory Therapy and Visual Acuity at 7 Years Among Patients With Intermediate, Posterior, or Panuveitis

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    JAMA. 2017; 317(19):1993-2005. doi: 10.1001/jama.2017.5103

    This study reports 7-year outcomes data for patients with uveitis randomized in the Multicenter Uveitis Steroid Treatment trial to receive an intravitreous fluocinolone acetonide implant vs prednisone or other immunosuppressant therapy.

  • Association Between Chlorthalidone Treatment of Systolic Hypertension and Long-term Survival

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    JAMA. 2011; 306(23):2588-2593. doi: 10.1001/jama.2011.1821
  • Effect of the Use and Timing of Bone Marrow Mononuclear Cell Delivery on Left Ventricular Function After Acute Myocardial Infarction: The TIME Randomized Trial

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    JAMA. 2012; 308(22):2380-2389. doi: 10.1001/jama.2012.28726
    Traverse and coauthors for the Cardiovascular Cell Therapy Research Network report on the effect on left ventricular function of the use and timing of bone marrow mononuclear cell delivery after acute myocardial infarction. In an accompanying Editorial, Marbán and Malliaras discuss the mixed results for bone marrow–derived cell therapy for ischemic heart disease.
  • Implementation of a Sensitive Troponin I Assay and Risk of Recurrent Myocardial Infarction and Death in Patients With Suspected Acute Coronary Syndrome

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    JAMA. 2011; 305(12):1210-1216. doi: 10.1001/jama.2011.338
  • Endovascular Thrombectomy for Acute Ischemic Stroke: A Meta-analysis

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    JAMA. 2015; 314(17):1832-1843. doi: 10.1001/jama.2015.13767

    precis

  • Ten-Year Follow-up After Initiation of Statin Therapy in Children With Familial Hypercholesterolemia

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    JAMA. 2014; 312(10):1055-1057. doi: 10.1001/jama.2014.8892
  • Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone

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    JAMA. 2017; 317(7):708-716. doi: 10.1001/jama.2016.21043

    This clinical trial compares the effects of testosterone gel vs placebo for 12 months on noncalcified coronary artery plaque volume in older men with low testosterone.

  • Effect of Spironolactone on Diastolic Function and Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction: The Aldo-DHF Randomized Controlled Trial

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    JAMA. 2013; 309(8):781-791. doi: 10.1001/jama.2013.905
    Edelmann and coauthors conducted a randomized controlled trial among 422 patients with heart failure with preserved ejection fraction to assess whether spironolactone is superior to placebo in improving diastolic function and maximal exercise capacity.
  • Maternal Body Mass Index and the Risk of Fetal Death, Stillbirth, and Infant Death: A Systematic Review and Meta-analysis

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    JAMA. 2014; 311(15):1536-1546. doi: 10.1001/jama.2014.2269

    In an effort to analyze the optimal maternal body mass index for lowering risk of fetal death, stillbirth, and infant death, Aune and colleagues conduct a systematic review and meta-analysis of cohort studies about this topic.

  • Nonalcoholic Fatty Liver and Insulin Resistance Among Petrochemical Workers

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    JAMA. 2005; 294(13):1615-1620. doi: 10.1001/jama.294.13.1618-b
  • A 38-Year-Old Man With Extensor Surface Papules

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    JAMA. 2015; 313(1):83-84. doi: 10.1001/jama.2014.15261
  • Reporting of Results in ClinicalTrials.gov and High-Impact Journals

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    JAMA. 2014; 311(10):1063-1065. doi: 10.1001/jama.2013.285634
  • Clinical Trial Evidence Supporting FDA Approval of Novel Therapeutic Agents, 2005-2012

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    JAMA. 2014; 311(4):368-377. doi: 10.1001/jama.2013.282034
  • Chronic Disease Prevention: Tobacco Avoidance, Physical Activity, and Nutrition for a Healthy Start

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    JAMA. 2016; 316(16):1645-1646. doi: 10.1001/jama.2016.14370

    This Viewpoint from the National Academy of Medicine's 2016 Vital Directions initiative proposes that the most effective way to prevent chronic disease in US adults is to promote policies that limit tobacco access, encourage physical activity, and uphold school nutrition standards among children.