This randomized clinical trial compares the effects of whole-body cooling vs usual care on death or disability at 18 to 22 months among infants with hypoxic-ischemic encephalopathy.
This randomized 2 × 2 factorial trial compares the effects of hypothermia depth (32.0°C vs 33.5°C) and duration (72 vs 120 hours) on death and disability among infants with moderate or severe hypoxic-ischemic encephalopathy.
This population epidemiology study used neonatal registry data to characterize trends in maternal and neonatal care, and morbidity and mortality of extremely preterm infants between 1993 and 2012.
This retrospective analysis of infants at National Institute of Child Health and Human Development Neonatal Research Network sites did not find differences in mortality or neonatal morbidity between trial participants and nonparticipants.
Shankaran and coauthors determine if longer duration cooling (120 hours), deeper cooling (32.0°C), or both is superior to cooling to 33.5°C for 72 hours in neonates who are full-term with moderate or severe hypoxic ischemic encephalopathy (HIE).
Barber and coauthors investigated outcomes among women undergoing surgery for vaginal prolapse and stress urinary incontinence by comparing sacrospinous ligament fixation and uterosacral ligament suspension and comparing perioperative behavioral therapy with pelvic floor muscle training and usual care in a multicenter, 2 × 2 factorial, randomized trial.
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