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  • A Man With a Nonblanchable Purpuric Rash

    Abstract Full Text
    JAMA. 2017; 317(22):2329-2330. doi: 10.1001/jama.2017.4954

    An older man presented with 4 weeks of diffuse rash and elbow and knee pain. The rash improved initially with prednisone but recurred at tapered dosing. Laboratory tests revealed normal blood cell counts, normal values for renal and hepatic panels, microscopic hematuria, and 1+ proteinuria. What would you do next?

  • JAMA August 23, 2016

    Figure 1: Study Overview

    Patient recruitment and subsequent selection for microarray analysis. DB indicates definite bacterial; DV, definite viral; HC, healthy control; HSP, Henoch-Schönlein purpura; JIA, juvenile idiopathic arthritis; PB, probable bacterial; PV, probable viral; SLE, systemic lupus erythematosus; U, unknown. aControls not used for signature discovery. bControls not used for signature validation. cDefinite meningococcal disease.
  • JAMA August 23, 2016

    Figure 3: Analysis Workflow

    Overall study pipeline showing sample handling, derivation of test and training sets, data processing, and analysis pipeline including application of 38-transcript elastic net classifier and 2-transcript disease risk score (DRS) classifier, to the group test set, the validation group data, and published (external) validation datasets. DB indicates definite bacterial; DV, definite viral; FC, fold change; FS-PLS, forward selection–partial least squares; HSP, Henoch-Schönlein purpura; JIA, juvenile idiopathic arthritis; PB, probable bacterial; PV, probable viral; SDE, significantly differentially expressed; SLE, systemic lupus erythematosus; U, unknown.
  • Henoch-Schönlein Purpura

    Abstract Full Text
    JAMA. 2012; 307(7):742-742. doi: 10.1001/jama.2012.81
  • Systemic Lupus Erythematosus with Chorea

    Abstract Full Text
    JAMA. 1963; 184(12):971-973. doi: 10.1001/jama.1963.73700250023021a
  • Heptinstall’s Pathology of the Kidney, vols 1 and 2

    Abstract Full Text
    JAMA. 2007; 297(18):2031-2035. doi: 10.1001/jama.297.18.2031