J.-K. Lee and coauthors performed a systematic review and meta-analysis to determine the association between survival and first-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors vs chemotherapy among patients with advanced non–small cell lung cancer with wild-type EGFR.
This randomized trial reports high rates of sustained virologic response in the first part of a open-label study of ombitasvir, paritaprevir (co-dosed with ritonavir), and dasabuvir with ribavirin for 63 patients with hepatitis C virus genotype 1 and human immunodeficiency virus 1 co-infection.
This Editorial discusses the use of PD-1 blockade in treating patients with metastatic melanoma in the KEYNOTE-1 trial.
This randomized clinical trial compares the overall response rate and safety of a proposed trastuzumab biosimilar vs trastuzumab and a taxane among women with ERBB2 (HER2)–positive metastatic breast cancer.
This randomized clinical trial compares the effects of 2 years of sublingual grass pollen immunotherapy vs placebo on nasal symptom scores in adults with moderate to severe seasonal allergic rhinitis.
This phase 1 trial evaluates safety and wound outcomes after transplant of genetically corrected autologous epidermal grafts onto wounds of patients with recessive dystrophic epidermolysis bullosa.
This randomized clinical trial compares the effects of physical rehabilitation vs usual care on length of stay of ICU patients with acute respiratory failure.
This narrative review summarizes recent advances in the prevention, diagnosis, and treatment of delirium and highlights critical areas for future research.
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