This Medical News article is an interview with psychiatrist Carlos A. Zarate Jr, MD, at the National Institute of Mental Health.
This randomized clinical trial compares the effects of sertraline vs placebo on depressive symptoms in patients with stage 3, 4, or 5 non–dialysis-dependent chronic kidney disease and major depressive disorder.
A 57-year-old man presented with a history of HIV, hyperlipidemia, and major depressive disorder reporting depression and insomnia. He was taking bupropion but recent life events led to increased depressive symptoms. How would you proceed?
This randomized clinical trial compares the effects on symptom remission of switching to bupropion, adding bupropion, or adding aripiprazole to baseline treatment among Veterans Affairs patients with antidepressant-resistant major depressive disorder.
This review offers guidance on medical and psychotherapeutic treatment options available for older frail patients with depression and who are taking several types of medications.
This randomized clinical trial investigates whether a collaborative care intervention, compared with usual care, reduces depressive symptoms and prevents more severe depression in older people with subclinical depression.
This Arts and Medicine essay reviews The One With Friends, a theatre workshop that addresses mental illness, loneliness, and the importance of human connection for young single adults through an imagined reunion of characters from the TV show Friends 10 years after the show ended.
This Medical News article discusses the use of consumer data for disease genomics research.
This randomized trial evaluated the effects on anxiety and depression symptoms of a multicomponent behavioral intervention delivered by lay health workers to adults functionally impaired by psychological distress in a conflict-affected area of Pakistan.
This cluster randomized clinical trial evaluates the effectiveness of a lay health worker–administered, primary care–based, culturally adapted psychological intervention with education and support, vs usual care with education and support, for common mental disorders in Zimbabwe.
This meta-analysis estimates the prevalence of depression, depressive symptoms, and suicidal ideation in medical students.
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