This Viewpoint discusses the roles of data monitoring committees (DMCs) in providing oversight of clinical trials and summarizes recommendations from the Clinical Trials Transformation Initiative for improving this oversight as a means of improving DMC processes and effectiveness.
This randomized clinical trial assesses the effectiveness of dexmedetomidine when added to standard care in patients with agitated delirium receiving mechanical ventilation.
This randomized clinical trial compares the efficacy and adverse effects of 2 cerebral embolic protection devices vs a shared control group in reducing ischemic central nervous system injury during surgical aortic valve replacement.
This randomized clinical trial compares the effects of hydrocortisone vs placebo on development of septic shock among intensive care patients with severe sepsis who were not in septic shock.
This randomized clinical trial determined that treatment with creatine monohydrate for at least 5 years did not improve clinical outcomes in patients with early Parkinson disease.
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