This pragmatic randomized trial compares the effects of a second anti–tumor necrosis factor (TNF) drug vs non–TNF-targeted biologic therapy among patients with rheumatoid arthritis for whom a first anti-TNF drug had failed.
This Viewpoint discusses the integration of precision medicine discoveries with the learning health care system via implementation science.
This study describes withdrawals, boxed warnings, and safety communications affecting pharmaceuticals and biologics approved by the US Food and Drug Administration between 2001 and 2010, and associations between characteristics known at the time of approval and those events.
This study uses risk scores from 2 studies to assess their accuracy in predicting cardiovascular events among patients with stable coronary heart disease.
This randomized clinical trial compares the effect of adding bevacizumab vs cetuximab to standard chemotherapy regimens on overall survival among patients with advanced or metastatic KRAS wild-type colorectal cancer.
This population epidemiology study uses Medicare administrative data to describe national trends in performance and outcomes of carotid endarterectomy and carotid artery stenting from 1999 to 2014 among fee-for-service Medicare beneficiaries aged 65 years or older.
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