This 2-stage randomized clinical trial compared lipid-lowering efficacy of 2 nonstatin therapies, ezetimibe and evolocumab, among patients with uncontrolled low-density lipoprotein cholesterol levels and intolerance to 2 or more statins.
Lincoff and coauthors determine whether addition of aleglitazar to standard medical therapy reduces cardiovascular morbidity and mortality among 7226 patients with type 2 diabetes mellitus (T2D) and a recent acute coronary syndrome (ACS).
This participant-level meta-analysis estimates the prevalence of PET scan–measured amyloid in Alzheimer disease participants and its associations with age, sex, education, cognitive function, and APOE genotype.
This meta-analysis explores the association of amyloid pathology with age, APOE genotype, sex, education, and presence of cognitive impairment among persons without dementia.
To investigate genetic risk variants for infantile hypertrophic pyloric stenosis, Feenstra and coauthors searched the genome for genetic associations and then validated findings in 3 independent case-control sample sets that included a total of 2664 cases and 4686 controls.
This cross-sectional study examines whether rare and common variants in the lipoprotein lipase gene are associated with early-onset coronary artery disease.
In a double-blind, placebo-controlled, parallel-group, randomized clinical trial with 613 patients, Dysken and coauthors investigated the use of vitamin E (alpha tocopherol), memantine, and a combination to slow progression of mild to moderate Alzheimer disease (AD). In an Editorial, Evans and coauthors discuss the best features in trials of AD therapy and a balance between treatment and prevention.
This observation trial reports that whole-exome sequencing provides a potential molecular diagnosis for patients referred for evaluation of suspected genetic conditions, including detection of rare genetic events and new mutations, contributing to disease.
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