This Clinical Evidence Synopsis summarizes a Cochrane review of trials comparing oxycodone with placebo and other opioids for treating cancer pain in adults.
Omuro and DeAngelis review the clinical management of malignant gliomas, including genetic and environmental risk factors such as cell phones, diagnostic pitfalls, symptom management, specific antitumor therapy, and common complications.
Raebel and colleagues compare use of opioid medications for chronic pain 1 year before bariatric surgery vs 1 year after in a retrospective cohort study of 11 719 US patients from 2005 through 2009. In an Editorial, Alford discusses risks associated with opioid use and decreasing the need for chronic opioid therapy.
This retrospective study compared risk of death among Medicaid patients in Tennessee initiating long-acting opioid therapy for chronic noncancer pain with patients taking anticonvulsants or cyclic antidepressants.
This randomized clinical trial compares the effects of whole-body cooling vs usual care on death or disability at 18 to 22 months among infants with hypoxic-ischemic encephalopathy.
This pharmacoepidemiology study uses NHANES data to describe trends in prescription drug use among US adults between 1999 and 2012.
This randomized clinical trial compares the effects of sedation with vs without dexmedetomidine on mortality and ventilator-free days in patients with sepsis.
This randomized trial compared improvement in functional outcomes among patients with low back pain discharged from the emergency department and receiving naproxen with either placebo, cyclobenzaprine, or oxycodone/acetaminophen.
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