http://jama.jamanetwork.com/ en-us Mon, 17 Dec 2012 00:00:00 GMT Tue, 01 Jan 2013 00:51:32 GMT Silverchair editor@jama.jamanetwork.com webmaster@jama.jamanetwork.com http://jama.jamanetwork.com/article.aspx?articleID=1356348 Wed, 05 Sep 2012 00:00:00 GMT Formenti SC, DeWyngaert J, Jozsef G, et al. <span class="paragraphSection">To the Editor: Adjuvant radiotherapy to the breast contributes to improved outcomes in breast cancer patients after breast preservation surgery. However, whole breast radiotherapy is associated with damage to the heart and lung, increased cardiovascular mortality, and lung cancer development, with risks that remain 15 to 20 years after treatment. These consequences occur when breast cancer patients are treated supine. Preliminary data on prone positioning suggest that radiation exposure to the heart and lung can be reduced compared with supine positioning with similar efficacy. To test the hypothesis that prone positioning is superior to standard supine positioning, we compared the volume of heart and lung within the radiation field in a prospective study of patients who underwent simulation in both positions.</span> 308 9 861 863 10.1001/2012.jama.10759 http://jama.jamanetwork.com/article.aspx?articleID=1356348