Linkage of Familial Amyotrophic Lateral Sclerosis With Frontotemporal Dementia to Chromosome 9q21-q22

Hosler BA, Siddique T, Sapp PC, et al. — Wed, 04 Oct 2000 00:00:00 GMT

ContextOccasionally, 2 or more major neurodegenerative diseases arise simultaneously. An understanding of the genetic bases of combined disorders, such as amyotrophic lateral sclerosis (ALS) with frontotemporal dementia (FTD), will likely provide insight into mechanisms of these and related neurodegenerative diseases.ObjectiveTo identify loci that contain genes whose defects cause ALS.DesignA genome-wide linkage analysis of 2 data sets from an ongoing study begun in the mid-1980s at 4 university research centers.SubjectsAn initial subset of 16 families (549 people) potentially informative for genetic analysis, in which 2 or more individuals were diagnosed as having ALS, identified from a Boston data set of 400 families and 4 families potentially informative (244 people) subsequently identified from a Chicago data set of more than 300 families to test a hypothesis based on findings from the Boston families.Main Outcome MeasuresLinkage calculations assuming autosomal dominant inheritance with age-dependent penetrance (a parametric logarithm-of-odds [lod] score of 1.0 or greater required for further study of a potential locus); crossover analysis involving the ALS-FTD locus.ResultsIn a set of families in which persons develop both ALS and FTD or either ALS or FTD alone, a genetic locus that is linked to ALS with FTD located between markers D9S301 and D9S167 was identified on human chromosome 9q21-q22. Families with ALS alone did not show linkage to this locus. Crossover analysis indicates this region covers approximately 17 cM.ConclusionThese data suggest that a defective gene located in the chromosome 9q21-q22 region may be linked to ALS with FTD.

JAMA: Frontotemporal Dementia Topic Collection

Linkage of Familial Amyotrophic Lateral Sclerosis With Frontotemporal Dementia to Chromosome 9q21-q22