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 Showing 1-20 of 22 Articles
Special Communication  FREE
Michelle M. Mello, JD, PhD, MPhil; David M. Studdert, LLB, ScD, MPH; Allen Kachalia, MD, JD

For many physicians, the prospect of being sued for medical malpractice is a singularly disturbing aspect of modern clinical practice. State legislatures have enacted tort reforms, such as caps on damages, in an effort to reduce the volume and costs of malpractice litigation. Attempts to introduce similar traditional ...

Editorial  FREE
William M. Sage, MD, JD
Crisis, it is said, means both danger and opportunity. In medical liability reform, however, greater opportunity may lie in noncrisis. In this issue of JAMA, Mello and colleagues1 offer data suggesting that no crisis of the conventional sort currently exists in the medical malpractice system.
Viewpoint  FREE
Michael B. Edmond, MD, MPH, MPA; Daniel J. Diekema, MD, MS; Eli N. Perencevich, MD, MS
Preventing transmission of pathogens in the health care setting with the use of personal protective equipment (PPE) has been an area of longstanding debate in the infection prevention community. Recently, reports of nosocomial transmission of Ebola virus to 2 nurses from the same patient in Texas (despite their use of ...
Original Investigation  FREE
J. Gustav Smith, MD; Kevin Luk; Christina-Alexandra Schulz, MSc; James C. Engert, PhD; Ron Do, PhD; George Hindy, MD; Gull Rukh, MSc; Line Dufresne, MSc; Peter Almgren, MSc; David S. Owens, MD; Tamara B. Harris, MD; Gina M. Peloso, PhD; Kathleen F. Kerr, PhD; Quenna Wong, MS; Albert V. Smith, PhD; Matthew J. Budoff, MD; Jerome I. Rotter, MD; L. Adrienne Cupples, PhD; Stephen Rich, PhD; Sekar Kathiresan, MD; Marju Orho-Melander, PhD; Vilmundur Gudnason, MD; Christopher J. O’Donnell, MD; Wendy S. Post, MD; George Thanassoulis, MD; for the Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) Extracoronary Calcium Working Group
Includes: Supplemental Content

Importance  Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.

Objective  To evaluate whether genetic data are consistent with an association between ...

Viewpoint  FREE
Julie A. Freischlag, MD; Melina R. Kibbe, MD
This Viewpoint discusses areas in which the practice of surgery has changed during the past several decades.
Viewpoint  FREE
Kenneth D. Mandl, MD, MPH
This Viewpoint discusses how health information technology and electronic health records (EHRs) could be transformed into platforms for public health responses to disease.
Editorial  FREE
Jonathan S. Berg, MD, PhD
This Editorial discusses possible contributions of genomic sequencing to progress in clinical care, from molecular diagnosis to improved outcomes.
Topics: genome; diagnosis
Original Investigation  FREE
Yaping Yang, PhD; Donna M. Muzny, MS; Fan Xia, PhD; Zhiyv Niu, PhD; Richard Person, PhD; Yan Ding, MD; Patricia Ward, MS; Alicia Braxton, MS; Min Wang, PhD; Christian Buhay, BS; Narayanan Veeraraghavan, PhD; Alicia Hawes, BS; Theodore Chiang, MS; Magalie Leduc, PhD; Joke Beuten, PhD; Jing Zhang, PhD; Weimin He, PhD; Jennifer Scull, PhD; Alecia Willis, PhD; Megan Landsverk, PhD; William J. Craigen, MD, PhD; Mir Reza Bekheirnia, MD; Asbjorg Stray-Pedersen, MD, PhD; Pengfei Liu, PhD; Shu Wen, PhD; Wendy Alcaraz, PhD; Hong Cui, PhD; Magdalena Walkiewicz, PhD; Jeffrey Reid, PhD; Matthew Bainbridge, PhD; Ankita Patel, PhD; Eric Boerwinkle, PhD; Arthur L. Beaudet, MD; James R. Lupski, MD, PhD; Sharon E. Plon, MD, PhD; Richard A. Gibbs, PhD; Christine M. Eng, MD
Includes: Supplemental Content

Importance  Clinical whole-exome sequencing is increasingly used for diagnostic evaluation of patients with suspected genetic disorders.

Objective  To perform clinical whole-exome sequencing and report (1) the rate of molecular diagnosis among phenotypic groups, (2) the spectrum of genetic alterations contributing to disease, and (3) the prevalence ...

Original Investigation  FREE
Hane Lee, PhD; Joshua L. Deignan, PhD; Naghmeh Dorrani, MS, CGC; Samuel P. Strom, PhD; Sibel Kantarci, PhD; Fabiola Quintero-Rivera, MD; Kingshuk Das, MD; Traci Toy, BS; Bret Harry, BS; Michael Yourshaw, PhD; Michelle Fox, MS, CGC; Brent L. Fogel, MD, PhD; Julian A. Martinez-Agosto, MD, PhD; Derek A. Wong, MD; Vivian Y. Chang, MD, MS; Perry B. Shieh, MD, PhD; Christina G. S. Palmer, PhD, CGC; Katrina M. Dipple, MD, PhD; Wayne W. Grody, MD, PhD; Eric Vilain, MD, PhD; Stanley F. Nelson, MD
Includes: Supplemental Content

Importance  Clinical exome sequencing (CES) is rapidly becoming a common molecular diagnostic test for individuals with rare genetic disorders.

Objective  To report on initial clinical indications for CES referrals and molecular diagnostic rates for different indications and for different test types.

Design, Setting, and Participants  ...

Viewpoint  FREE
Lawrence O. Gostin, JD, LLD; James G. Hodge Jr, JD, LLM; Scott Burris, JD
This Viewpoint discusses the health system preparedness required for the United States to handle a public health emergency like Ebola.
Viewpoint  FREE
Victor R. Fuchs, PhD
This Viewpoint discusses the economics of the US health care system.
Viewpoint  FREE
Paul J. Hershberger, PhD; Dean A. Bricker, MD
This Viewpoint discusses the benefit to both patients and physicians of implementing patient-centered approaches to care.
Preliminary Communication  FREE
Ilan Youngster, MD, MMSc; George H. Russell, MD, MSc; Christina Pindar, BA; Tomer Ziv-Baran, PhD; Jenny Sauk, MD; Elizabeth L. Hohmann, MD
Includes: Supplemental Content

Importance  Fecal microbiota transplantation (FMT) has been shown to be effective in treating relapsing or refractory Clostridium difficile infection, but practical barriers and safety concerns have prevented its widespread use.

Objective  To evaluate the safety and rate of resolution of diarrhea following administration of frozen FMT ...

Research Letter 
Jeffrey S. Gerber, MD, PhD; Priya A. Prasad, MPH; Alexander G. Fiks, MD, MSCE; A. Russell Localio, PhD; Louis M. Bell, MD; Ron Keren, MD, MPH; Theoklis E. Zaoutis, MD, MSCE
Includes: Supplemental Content
This follow-up to a randomized trial found that an intervention to reduce inappropriate antibiotic prescribing was effective only as long as audit and feedback to clinicians was in place.
Viewpoint  FREE
Andrew S. Boozary, MD, MPP; Paul E. Farmer, MD, PhD; Ashish K. Jha, MD, MPH
This Viewpoint examines the infrastructure and quality of health systems in West Africa against the backdrop of the Ebola outbreak.
JAMA Patient Page  FREE
Jill Jin, MD, MPH
Graphic Jump Location
Viewpoint  FREE
Christopher M. Jones, PharmD, MPH; Peter Lurie, MD, MPH; Janet Woodcock, MD
This Viewpoint discusses approaches to preventing deaths attributable to prescription opioid overdose.
From the JAMA Network  FREE
Bruce M. Wolfe, MD; Steven H. Belle, PhD
JAMA SurgeryLong-term Outcomes of Bariatric Surgery: A National Institutes of Health SymposiumAnita P. Courcoulas, MD, MPH; Susan Z. Yanovski, MD; Denise Bonds, MD, MPH; Thomas L. Eggerman, MD; Mary Horlick, MD; Myrlene A. Staten, MD; David E. Arterburn, MD, MPHImportance The clinical evidence base demonstrating bariatric surgery’s health benefits is ...
Original Investigation  FREE
Tiziana Bove, MD; Alberto Zangrillo, MD; Fabio Guarracino, MD; Gabriele Alvaro, MD; Bruno Persi, MD; Enivarco Maglioni, MD; Nicola Galdieri, MD; Marco Comis, MD; Fabio Caramelli, MD; Daniela C. Pasero, MD; Giovanni Pala, MD; Massimo Renzini, MD; Massimiliano Conte, MD; Gianluca Paternoster, MD; Blanca Martinez, MD; Fulvio Pinelli, MD; Mario Frontini, MD; Maria C. Zucchetti, MD; Federico Pappalardo, MD; Bruno Amantea, MD; Annamaria Camata, MD; Antonio Pisano, MD; Claudio Verdecchia, MD; Erika Dal Checco, MD; Claudia Cariello, MD; Luana Faita, MD; Rubia Baldassarri, MD; Anna M. Scandroglio, MD; Omar Saleh, MD; Rosalba Lembo, MSc; Maria G. Calabrò, MD; Rinaldo Bellomo, MD; Giovanni Landoni, MD
Includes: Supplemental Content

Importance  No effective pharmaceutical agents have yet been identified to treat acute kidney injury after cardiac surgery.

Objective  To determine whether fenoldopam reduces the need for renal replacement therapy in critically ill cardiac surgery patients with acute kidney injury.

Design, Setting, and Participants  Multicenter, randomized, ...

Editorial  FREE
Mary L. Disis, MD; Thomas J. Easley; Howard Bauchner, MD

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