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 Showing 1-15 of 15 Articles
Editorial  FREE
Marin H. Kollef, MD; Scott T. Micek, PharmD
Clinicians working in the intensive care unit (ICU) setting encounter the dilemma of prescribing antibiotics to treat critically ill patients with serious infections while minimizing the emergence and spread of antimicrobial resistance. Delaying the administration of appropriate antibiotic therapy (ie, an antibiotic regimen active against the causative pathogen based on ...
Original Investigation  FREE
Evelien A. N. Oostdijk, MD, PhD; Jozef Kesecioglu, MD, PhD; Marcus J. Schultz, MD, PhD; Caroline E. Visser, MD, PhD; Evert de Jonge, MD, PhD; Einar H. R. van Essen, MD; Alexandra T. Bernards, MD, PhD; Ilse Purmer, MD; Roland Brimicombe, MD, PhD; Dennis Bergmans, MD, PhD; Frank van Tiel, MD, PhD; Frank H. Bosch, MD, PhD; Ellen Mascini, MD, PhD; Arjanne van Griethuysen, MD, PhD; Alexander Bindels, MD, PhD; Arjan Jansz, MD; Fred (A.) L. van Steveninck, MD, PhD; Wil C. van der Zwet, MD, PhD; Jan Willem Fijen, MD, PhD; Steven Thijsen, MD, PhD; Remko de Jong, MD; Joke Oudbier, MD; Adrienne Raben, MD; Eric van der Vorm, MD, PhD; Mirelle Koeman, MD, PhD; Philip Rothbarth, MD, PhD; Annemieke Rijkeboer, MD; Paul Gruteke, MD; Helga Hart-Sweet, MD; Paul Peerbooms, MD, PhD; Lex J. Winsser, MD†; Anne-Marie W. van Elsacker-Niele, MD, PhD; Kees Demmendaal, MD; Afke Brandenburg, MD, PhD; Anne Marie G.A. de Smet, MD, PhD; Marc J. M. Bonten, MD, PhD
Includes: Supplemental Content

Importance  Selective decontamination of the digestive tract (SDD) and selective oropharyngeal decontamination (SOD) are prophylactic antibiotic regimens used in intensive care units (ICUs) and associated with improved patient outcome. Controversy exists regarding the relative effects of both measures on patient outcome and antibiotic resistance.

Objective  To ...

From the JAMA Network  FREE
Bruce M. Wolfe, MD; Steven H. Belle, PhD
JAMA SurgeryLong-term Outcomes of Bariatric Surgery: A National Institutes of Health SymposiumAnita P. Courcoulas, MD, MPH; Susan Z. Yanovski, MD; Denise Bonds, MD, MPH; Thomas L. Eggerman, MD; Mary Horlick, MD; Myrlene A. Staten, MD; David E. Arterburn, MD, MPHImportance The clinical evidence base demonstrating bariatric surgery’s health benefits is ...
Original Investigation  FREE
Karin Amrein, MD, MSc; Christian Schnedl, MD; Alexander Holl, MD; Regina Riedl, MSc; Kenneth B. Christopher, MD; Christoph Pachler, MD; Tadeja Urbanic Purkart, MD; Andreas Waltensdorfer, MD; Andreas Münch, MD; Helga Warnkross, MD; Tatjana Stojakovic, MD; Egbert Bisping, MD; Wolfgang Toller, MD; Karl-Heinz Smolle, MD; Andrea Berghold, PhD; Thomas R. Pieber, MD; Harald Dobnig, MD
Includes: Supplemental Content

Importance  Low vitamin D status is linked to increased mortality and morbidity in patients who are critically ill. It is unknown if this association is causal.

Objective  To investigate whether a vitamin D3 treatment regimen intended to restore and maintain normal vitamin D status over ...

Original Investigation  FREE
Tiziana Bove, MD; Alberto Zangrillo, MD; Fabio Guarracino, MD; Gabriele Alvaro, MD; Bruno Persi, MD; Enivarco Maglioni, MD; Nicola Galdieri, MD; Marco Comis, MD; Fabio Caramelli, MD; Daniela C. Pasero, MD; Giovanni Pala, MD; Massimo Renzini, MD; Massimiliano Conte, MD; Gianluca Paternoster, MD; Blanca Martinez, MD; Fulvio Pinelli, MD; Mario Frontini, MD; Maria C. Zucchetti, MD; Federico Pappalardo, MD; Bruno Amantea, MD; Annamaria Camata, MD; Antonio Pisano, MD; Claudio Verdecchia, MD; Erika Dal Checco, MD; Claudia Cariello, MD; Luana Faita, MD; Rubia Baldassarri, MD; Anna M. Scandroglio, MD; Omar Saleh, MD; Rosalba Lembo, MSc; Maria G. Calabrò, MD; Rinaldo Bellomo, MD; Giovanni Landoni, MD
Includes: Supplemental Content

Importance  No effective pharmaceutical agents have yet been identified to treat acute kidney injury after cardiac surgery.

Objective  To determine whether fenoldopam reduces the need for renal replacement therapy in critically ill cardiac surgery patients with acute kidney injury.

Design, Setting, and Participants  Multicenter, randomized, ...

Editorial  FREE
Mary L. Disis, MD; Thomas J. Easley; Howard Bauchner, MD
Viewpoint  FREE
Michelle M. Doty, PhD, MPH; David Blumenthal, MD; Sara R. Collins, PhD
This Viewpoint examines health insurance coverage and access to health care for Latino adults under the Affordable Care Act.
Editorial  FREE
Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA
Poverty and war are among the two greatest threats to health and well-being. In virtually every study, poverty emerges as a major risk factor for most diseases. The tragedies of 9/11 and the current conflicts in the Middle East are painful reminders of the human toll and societal cost of ...
Topics: climate change
Special Communication  FREE
Jonathan A. Patz, MD, MPH; Howard Frumkin, MD, DrPH; Tracey Holloway, PhD; Daniel J. Vimont, PhD; Andrew Haines, MBBS, MD

Importance  Health is inextricably linked to climate change. It is important for clinicians to understand this relationship in order to discuss associated health risks with their patients and to inform public policy.

Objectives  To provide new US-based temperature projections from downscaled climate modeling and to review ...

Viewpoint  FREE
Hoangmai H. Pham, MD, MPH; Melissa Cohen, JD, MPA; Patrick H. Conway, MD, MSc
Includes: Supplemental Content
This Viewpoint discusses the evolution of the Centers for Medicare & Medicaid Services’ Pioneer accountable care organization model.
Viewpoint  FREE
Lawrence O. Gostin, JD; Belinda H. Reeve, PhD; Marice Ashe, JD, MPH
This Viewpoint discusses the role that boards of health have had throughout history in relation to the soda portion rule in New York City.
Viewpoint  FREE
Coleen A. Boyle, PhD; James M. Perrin, MD; Virginia A. Moyer, MD, MPH
Includes: Supplemental Content
This Viewpoint discusses clinical preventive services in children and adolescents and provides important insights into screening practices in the United States
Viewpoint  FREE
Thomas R. Frieden, MD, MPH; Karen F. Brudney, MD; Anthony D. Harries, MD, FRCP
This Viewpoint discusses the importance of innovation and persistence in tuburculosis control programs.
Topics: tuberculosis
Viewpoint  FREE
Lori Frank, PhD; Ethan Basch, MD; Joe V. Selby, MD, MPH; For the Patient-Centered Outcomes Research Institute
This Viewpoint discusses the meaning of patient-centeredness in research and reasons for conducting patient-centered outcomes research.
Viewpoint  FREE
Luis T. Sanchez, MD
This Viewpoint discusses the problem of disruptive behavior among physicians and offers guidance for developing a medical culture of safety with clear expectations and standards.

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