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 Showing 1-9 of 9 Articles
Medical News & Perspectives  FREE
Bridget M. Kuehn, MSJ

This Medical News and Perspectives article explores the biological mechanisms underlying brain resilience that could help inform therapeutic strategies to mitigate cognitive decline.

Viewpoint  FREE
Joseph V. Selby, MD; Laura Forsythe, PhD; Harold C. Sox, MD

This Viewpoint describes the role of stakeholders in developing research questions, reviewing research applications, and conducting research as part of the Patient-Centered Outcomes Research Institute research enterprise.

Comment & Response  FREE
Bronwyn A. Kingwell, PhD; Anuradha Aggarwal, FRACP, PhD; Kellie M. D’Orsa, DMU; Melissa F. Formosa, BSc; Anthony J. White, FRACP, PhD; Ravi Savarirayan, FRACP, MD; Anthony M. Dart, DPhil, FRCP

To the Editor We wish to retract the article “Effect of Perindopril on Large Artery Stiffness and Aortic Root Diameter in Patients With Marfan Syndrome: A Randomized Controlled Trial,” published in the October 3, 2007, issue of JAMA,1 based on inadequate validation of primary data sources ...

Viewpoint  FREE
Nina L. Hunter, PhD; Kathryn M. O’Callaghan, BSE; Robert M. Califf, MD
Includes: Supplemental Content

This Viewpoint discusses the conceptual framework of the Precision Medicine Initiative that could lead to improved health by more effectively matching medical products to the needs and preferences of patients and care partners.

Viewpoint  FREE
Elizabeth A. McGlynn, PhD; Kathryn M. McDonald, MM; Christine K. Cassel, MD

This Viewpoint discusses the newly released Institute of Medicine report about diagnostic error and the most effective strategies for improving the diagnostic process.

Original Investigation  FREE
Mihai Gheorghiade, MD; Stephen J. Greene, MD; Javed Butler, MD, MPH, MBA; Gerasimos Filippatos, MD; Carolyn S. P. Lam, MBBS; Aldo P. Maggioni, MD; Piotr Ponikowski, MD; Sanjiv J. Shah, MD; Scott D. Solomon, MD; Elisabeth Kraigher-Krainer, MD; Eliana T. Samano, MD; Katharina Müller, DiplStat; Lothar Roessig, MD; Burkert Pieske, MD; for the SOCRATES-REDUCED Investigators and Coordinators
Includes: Supplemental Content

Importance  Worsening chronic heart failure (HF) is a major public health problem.

Objective  To determine the optimal dose and tolerability of vericiguat, a soluble guanylate cyclase stimulator, in patients with worsening chronic HF and reduced left ventricular ejection fraction (LVEF).

Design, Setting, and Participants  Dose-finding ...

Viewpoint  FREE
Therese Hesketh, PhD, FFPH; Xudong Zhou, PhD; Yun Wang, MPhil

This Viewpoint discusses aspects of the one-child policy in China and speculates on the future of the population with the newly announced two-child policy.

Viewpoint  FREE
Jeffrey W. Swanson, PhD; Richard J. Bonnie, LLB; Paul S. Appelbaum, MD

This Viewpoint calls for investment in suicide prevention research commensurate with the social burden of suicide in the United States, with an emphasis on how to limit access to firearms among people at risk for self-harm.

Viewpoint  FREE
Thomas R. Blair, MD, MS; Randall T. Espinoza, MD, MPH

This Viewpoint describes how Medicare and Medicaid created gaps in inpatient and outpatient mental health services and discusses how pending health reform legislation might close these gaps.

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