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 Showing 1-18 of 18 Articles
Viewpoint  FREE
Brian W. Powers, AB; Sreekanth K. Chaguturu, MD; Timothy G. Ferris, MD, MPH
This Viewpoint discusses the potential of high-risk care management programs that are practice-based, payer-catalyzed, and purchaser-supported to deliver better care at lower cost.
Viewpoint  FREE
John J. Marini, MD; Jean-Louis Vincent, MD, PhD; Djillali Annane, MD
This Viewpoint discusses new challenges and opportunities related to the care of critically ill patients.
Editorial  FREE
Didier Pittet, MD, MS; Derek C. Angus, MD, MPH
With increasing concern about health care–associated infections and transmission of multidrug-resistant organisms (MDROs), there has been substantial support for universal decolonization strategies, especially for high-risk patients, such as those in the intensive care unit (ICU). One such strategy that is being adopted widely is the use of daily chlorhexidine bathing. ...
Editorial  FREE
Sangeeta Mehta, MD, FRCPC
Light sedation1 or no sedation2 has become the therapeutic goal in critically ill adults. Large randomized trials3- 5 and systematic reviews6,7 have demonstrated that this goal is feasible, safe, and beneficial. The benefits include shorter durations of mechanical ventilation and stay in the intensive care unit (ICU).2- 4 However, prospective ...
Original Investigation  FREE
Martha A. Q. Curley, RN, PhD; David Wypij, PhD; R. Scott Watson, MD, MPH; Mary Jo C. Grant, APRN, PhD; Lisa A. Asaro, MS; Ira M. Cheifetz, MD; Brenda L. Dodson, PharmD; Linda S. Franck, RN, PhD; Rainer G. Gedeit, MD; Derek C. Angus, MD, MPH; Michael A. Matthay, MD; for the RESTORE Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
Includes: Supplemental Content

Importance  Protocolized sedation improves clinical outcomes in critically ill adults, but its effect in children is unknown.

Objective  To determine whether critically ill children managed with a nurse-implemented, goal-directed sedation protocol experience fewer days of mechanical ventilation than patients receiving usual care.

Design, Setting, and Participants...

Original Investigation  FREE
Michael J. Noto, MD, PhD; Henry J. Domenico, MS; Daniel W. Byrne, MS; Tom Talbot, MD, MPH; Todd W. Rice, MD, MSc; Gordon R. Bernard, MD; Arthur P. Wheeler, MD
Includes: Supplemental Content

Importance  Daily bathing of critically ill patients with the broad-spectrum, topical antimicrobial agent chlorhexidine is widely performed and may reduce health care–associated infections.

Objective  To determine if daily bathing of critically ill patients with chlorhexidine decreases the incidence of health care–associated infections.

Design, Setting, and Participants...

Viewpoint  FREE
Bernard Lo, MD
This Viewpoint discusses the benefits, challenges, and risks of sharing clinical trial findings and data.
Viewpoint  FREE
Scott Y. H. Kim, MD, PhD; Franklin G. Miller, PhD
This Viewpoint debates the guidance on ethics for studies that compare interventions within established standards of care.
Viewpoint  FREE
Eli Y. Adashi, MD, MS; Robert P. Kocher, MD
This Viewpoint discusses the findings of the Government Accountability Office, revisits the premise of physician self-referral, surveys the relevant statutory and regulatory framework, and explores potential solutions to this vexing and costly challenge
Viewpoint  FREE
Mitesh S. Patel, MD, MBA, MS; David A. Asch, MD, MBA; Kevin G. Volpp, MD, PhD
This Viewpoint discusses issues that prevent wearable medical devices from effectively bridging the gap between recording information and changing health-related behavior.
Should the FDA regulate laboratory-developed diagnostic tests? —Yes.
Viewpoint  FREE
James P. Evans, MD, PhD; Michael S. Watson, PhD
This Viewpoint discusses potential drawbacks of regulation meant to to ensure the quality, safety, and validity of laboratory-developed diagnostic tests.
Viewpoint  FREE
James M. Shultz, MS, PhD; Florence Baingana, MB, ChB, MMed (Psychiatry), MSc (HPPF); Yuval Neria, PhD
This Viewpoint discusses the emotional and psychological effect Ebola virus disease has on individuals, communities, and countries that have struggled with outbreaks.
Viewpoint  FREE
John E. McDonough, DrPH, MPA; Eli Y. Adashi, MD, MS
This Viewpoint traces the origins of the Affordable Care Act’s employer mandate provision, delineates its all-important rationale, and discusses the likelihood and consequences of its potential repeal.
Viewpoint  FREE
George A. Gellert, MD, MPH, MPA; Ricardo Ramirez, LVN; S. Luke Webster, MD
Includes: Supplemental Content
This Viewpoint argues that the increasing use of medical scribers to record patient data will impede the development of electronic health record management systems.
Viewpoint  FREE
Marc B. Garnick, MD
This Viewpoint discusses the need for stricter controls for the use of testosterone replacement therapy.
Viewpoint  FREE
Christopher J. L. Murray, MD, DPhil
This Viewpoint discusses the need for improvement in both efficiency and quality of antiretroviral therapy programs in developing countries.
Viewpoint 
Kathy L. Hudson, PhD; Francis S. Collins, MD, PhD
This Viewpoint advocates initiating greater transparency in reporting results of clinical trials as a responsibility that will benefit the health of many.
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