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Basic View | Expanded View
 Showing 1-20 of 25 Articles
Viewpoint  FREE
Lawrence O. Gostin, JD; Henry A. Waxman, JD; William Foege, MD, MPH
The Ebola epidemic is projected to affect tens of thousands in Sierra Leone, Liberia, and Guinea, with immense economic and social costs. Even in the United States, where only 1 patient with Ebola virus disease has died, the disease has spurred public fear, tested the readiness of the public health ...
Viewpoint  FREE
Kathy L. Hudson, PhD; Francis S. Collins, MD, MPH
This Viewpoint advocates initiating greater transparency in reporting results of clinical trials as a responsibility that will benefit the health of many.
Editorial  FREE
Bradley S. Dixon, MD
Hyperkalemia is a commonly encountered clinical problem and has been reported in up to 10% of hospitalized patients, with 10% to 38% of those episodes associated with medications that block the renin-angiotensin-aldosterone system (RAAS).1 Mortality has been shown to be increased in patients with hyperkalemia even after accounting for other ...
Editorial  FREE
Raymond J. Gibbons, MD
This Viewpoint discusses the use of screening coronary computed tomographic angiography in asymptomatic patients with diabetes.
Editorial  FREE
J. Michael Gaziano, MD, MPH; Philip Greenland, MD
This Editorial discusses when aspirin should be used to prevent vascular events and the factors that should be discussed in decision making.
Original Investigation  FREE
Mikhail Kosiborod, MD; Henrik S. Rasmussen, MD, PhD; Philip Lavin, PhD; Wajeh Y. Qunibi, MD; Bruce Spinowitz, MD; David Packham, MD; Simon D. Roger, MD; Alex Yang, MD; Edgar Lerma, MD; Bhupinder Singh, MD
Includes: Supplemental Content

Importance  Hyperkalemia is a common electrolyte abnormality that may be difficult to manage because of a lack of effective therapies. Sodium zirconium cyclosilicate is a nonabsorbed cation exchanger that selectively binds potassium in the intestine.

Objective  To evaluate the efficacy and safety of zirconium cyclosilicate for ...

Original Investigation  FREE
Joseph B. Muhlestein, MD; Donald L. Lappé, MD; Joao A. C. Lima, MD; Boaz D. Rosen, MD; Heidi T. May, PhD; Stacey Knight, PhD; David A. Bluemke, MD, PhD; Steven R. Towner, MD; Viet Le, PA; Tami L. Bair, BS; Andrea L. Vavere, MS; Jeffrey L. Anderson, MD
Includes: Supplemental Content

Importance  Coronary artery disease (CAD) is a major cause of cardiovascular morbidity and mortality in patients with diabetes mellitus, yet CAD often is asymptomatic prior to myocardial infarction (MI) and coronary death.

Objective  To assess whether routine screening for CAD by coronary computed tomography angiography (CCTA) ...

Original Investigation  FREE
Yasuo Ikeda, MD; Kazuyuki Shimada, MD; Tamio Teramoto, MD; Shinichiro Uchiyama, MD; Tsutomu Yamazaki, MD; Shinichi Oikawa, MD; Masahiro Sugawara, MD; Katsuyuki Ando, MD; Mitsuru Murata, MD; Kenji Yokoyama, MD; Naoki Ishizuka, PhD
Includes: Supplemental Content

Importance  Prevention of atherosclerotic cardiovascular diseases is an important public health priority in Japan due to an aging population.

Objective  To determine whether daily, low-dose aspirin reduces the incidence of cardiovascular events in older Japanese patients with multiple atherosclerotic risk factors.

Design, Setting, and Participants  ...

Editorial  FREE
Wolfgang C. Winkelmayer, MD, MPH, ScD; Kevin W. Finkel, MD
Acute kidney injury (AKI) is a serious complication of surgery and other severe health events (eg, sepsis). Its most severe form, AKI requiring dialysis, occurred during almost 164 000 hospitalizations in the United States in 2009 and was associated with almost 39 000 deaths.1 The incidence of AKI has been ...
Original Investigation  FREE
Greg A. Knoll, MD; Atul Humar, MD; Dean Fergusson, PhD; Olwyn Johnston, MD; Andrew A. House, MD; S. Joseph Kim, MD, PhD; Tim Ramsay, PhD; Michaël Chassé, MD; Xiaoli Pang, MD; Jeff Zaltzman, MD; Sandra Cockfield, MD; Marcelo Cantarovich, MD; Martin Karpinski, MD; Louise Lebel, BScN; John S. Gill, MD, MS
Includes: Supplemental Content

Importance  BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Viral reactivation occurs first in the urine (BK viruria) and is associated with a high risk of transplant failure. There are currently no therapies to prevent or treat BK virus infection. Quinolone ...

Original Investigation  FREE
Amit X. Garg, MD, PhD; Andrea Kurz, MD; Daniel I. Sessler, MD; Meaghan Cuerden, MSc; Andrea Robinson, BSc; Marko Mrkobrada, MD; Chirag R. Parikh, MD, PhD; Richard Mizera, MD; Philip M. Jones, MD, MSc; Maria Tiboni, MD; Adrià Font, MD; Virginia Cegarra, MD; Maria Fernanda Rojas Gomez, MD; Christian S. Meyhoff, MD, PhD; Tomas VanHelder, MD, PhD; Matthew T. V. Chan, MBBS; David Torres, MD, MSc; Joel Parlow, MD, MSc; Miriam de Nadal Clanchet, MD, PhD; Mohammed Amir, MBBS; Seyed Javad Bidgoli, MD; Laura Pasin, MD; Kristian Martinsen, MD; German Malaga, MD, MSc; Paul Myles, MD, MPH; Rey Acedillo, MD; Pavel S. Roshanov, MSc; Michael Walsh, MD, PhD; George Dresser, MD, PhD; Priya Kumar, MD; Edith Fleischmann, MD; Juan Carlos Villar, MD, PhD; Thomas Painter, MBChB; Bruce Biccard, MD, PhD; Sergio Bergese, MD; Sadeesh Srinathan, MD, MSc; Juan P. Cata, MD; Vincent Chan, MD; Bhupendra Mehra, MBBS, MS; Duminda N. Wijeysundera, MD, PhD; Kate Leslie, MD; Patrice Forget, MD, PhD; Richard Whitlock, MD, PhD; Salim Yusuf, DPhil; P. J. Devereaux, MD, PhD; for the POISE-2 Investigators
Includes: Supplemental Content

Importance  Acute kidney injury, a common complication of surgery, is associated with poor outcomes and high health care costs. Some studies suggest aspirin or clonidine administered during the perioperative period reduces the risk of acute kidney injury; however, these effects are uncertain and each intervention has the ...

Original Investigation  FREE
Rakhi P. Naik, MD, MHS; Vimal K. Derebail, MD; Morgan E. Grams, MD; Nora Franceschini, MD; Paul L. Auer, PhD; Gina M. Peloso, PhD; Bessie A. Young, MD; Guillaume Lettre, PhD; Carmen A. Peralta, MD; Ronit Katz, DPhil; Hyacinth I. Hyacinth, MD; Rakale C. Quarells, PhD; Megan L. Grove, MS; Alexander G. Bick; Pierre Fontanillas, PhD; Stephen S. Rich, PhD; Joshua D. Smith; Eric Boerwinkle, PhD; Wayne D. Rosamond, PhD; Kaoru Ito, MD; Sophie Lanzkron, MD; Josef Coresh, MD; Adolfo Correa, MD; Gloria E. Sarto, MD; Nigel S. Key, MBChB; David R. Jacobs, PhD; Sekar Kathiresan, MD; Kirsten Bibbins-Domingo, MD; Abhijit V. Kshirsagar, MD; James G. Wilson, MD; Alexander P. Reiner, MD
Includes: Supplemental Content

Importance  The association between sickle cell trait (SCT) and chronic kidney disease (CKD) is uncertain.

Objective  To describe the relationship between SCT and CKD and albuminuria in self-identified African Americans.

Design, Setting, and Participants  Using 5 large, prospective, US population-based studies (the Atherosclerosis Risk in ...

Viewpoint  FREE
Jessica L. Barrington-Trimis, PhD, MS, MA; Jonathan M. Samet, MD, MS; Rob McConnell, MD
This Viewpoint examines the flavorings added to e-cigarettes and the potential respiratory risks they may pose.
Viewpoint  FREE
Aaron McKethan, PhD; Ashish K. Jha, MD, MPH
This Viewpoint discusses options for developing more effective pay-for-performance programs.
Original Investigation  FREE
Robert A. Fowler, MDCM, MS; Nicole Mittmann, MSc, PhD; William Geerts, MD, MSc; Diane Heels-Ansdell, MSc; Michael K. Gould, MD, MS; Gordon Guyatt, MD; Murray Krahn, MD, MSc; Simon Finfer, MD; Ruxandra Pinto, PhD; Brian Chan, BSc; Orges Ormanidhi, MSc; Yaseen Arabi, MD; Ismael Qushmaq, MD; Marcelo G. Rocha, MD; Peter Dodek, MD, MHSc; Lauralyn McIntyre, MD, MSc; Richard Hall, MD, PhD; Niall D. Ferguson, MD, MSc; Sangeeta Mehta, MD; John C. Marshall, MD; Christopher James Doig, MD, MSc; John Muscedere, MD; Michael J Jacka, MD, MSc, MBA; James R. Klinger, MD; Nicholas Vlahakis, MBBS; Neil Orford, MBBS; Ian Seppelt, MD; Yoanna K. Skrobik, MD; Sachin Sud, MD, MSc; John F. Cade, MD; Jamie Cooper, MD; Deborah Cook, MD, MSc; for the Canadian Critical Care Trials Group and the Australia and New Zealand Intensive Care Society Clinical Trials Group
Includes: Supplemental Content

Importance  Venous thromboembolism (VTE) is a common complication of acute illness, and its prevention is a ubiquitous aspect of inpatient care. A multicenter blinded, randomized trial compared the effectiveness of the most common pharmocoprevention strategies, unfractionated heparin (UFH) and the low-molecular-weight heparin (LMWH) dalteparin, finding no difference ...

Editorial  FREE
William M. Sage, MD, JD
Crisis, it is said, means both danger and opportunity. In medical liability reform, however, greater opportunity may lie in noncrisis. In this issue of JAMA, Mello and colleagues1 offer data suggesting that no crisis of the conventional sort currently exists in the medical malpractice system.
Special Communication  FREE
Michelle M. Mello, JD, PhD, MPhil; David M. Studdert, LLB, ScD, MPH; Allen Kachalia, MD, JD

For many physicians, the prospect of being sued for medical malpractice is a singularly disturbing aspect of modern clinical practice. State legislatures have enacted tort reforms, such as caps on damages, in an effort to reduce the volume and costs of malpractice litigation. Attempts to introduce similar traditional ...

Viewpoint  FREE
Michael B. Edmond, MD, MPH, MPA; Daniel J. Diekema, MD, MS; Eli N. Perencevich, MD, MS
Preventing transmission of pathogens in the health care setting with the use of personal protective equipment (PPE) has been an area of longstanding debate in the infection prevention community. Recently, reports of nosocomial transmission of Ebola virus to 2 nurses from the same patient in Texas (despite their use of ...
Viewpoint  FREE
Kenneth D. Mandl, MD, MPH
This Viewpoint discusses how health information technology and electronic health records (EHRs) could be transformed into platforms for public health responses to disease.
Viewpoint  FREE
Lawrence O. Gostin, JD, LLD; James G. Hodge Jr, JD, LLM; Scott Burris, JD
This Viewpoint discusses the health system preparedness required for the United States to handle a public health emergency like Ebola.

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