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 Showing 1-20 of 23 Articles

Carbapenem-resistant Enterobacteriaceae (CRE) may be the most concerning contemporary antibiotic resistance threat. Enterobacteriaceae comprise a large group of bacteria, including Escherichia coli and Klebsiella pneumoniae, and are common causes of health care–associated and community-acquired infections. Carbapenems, such as imipenem, meropenem, ertapenem, and doripenem are among the broadest-spectrum and ...

Original Investigation  FREE
Carlos G. Grijalva, MD, MPH; Yuwei Zhu, MD, MS; Derek J. Williams, MD, MPH; Wesley H. Self, MD, MPH; Krow Ampofo, MD; Andrew T. Pavia, MD; Chris R. Stockmann, MSc; Jonathan McCullers, MD; Sandra R. Arnold, MD; Richard G. Wunderink, MD; Evan J. Anderson, MD; Stephen Lindstrom, PhD; Alicia M. Fry, MD, MPH; Ivo M. Foppa, ScD, MD; Lyn Finelli, DrPH, MS; Anna M. Bramley, MPH; Seema Jain, MD; Marie R. Griffin, MD, MPH; Kathryn M. Edwards, MD
Includes: Supplemental Content

Importance  Few studies have evaluated the relationship between influenza vaccination and pneumonia, a serious complication of influenza infection.

Objective  To assess the association between influenza vaccination status and hospitalization for community-acquired laboratory-confirmed influenza pneumonia.

Design, Setting, and Participants  The Etiology of Pneumonia in the Community ...

Original Investigation  FREE
Alice Y. Guh, MD, MPH; Sandra N. Bulens, MPH; Yi Mu, PhD; Jesse T. Jacob, MD; Jessica Reno, MPH; Janine Scott, MPH; Lucy E. Wilson, MD, ScM; Elisabeth Vaeth, MPH; Ruth Lynfield, MD; Kristin M. Shaw, MPH; Paula M. Snippes Vagnone, MT(ASCP); Wendy M. Bamberg, MD; Sarah J. Janelle, MPH; Ghinwa Dumyati, MD; Cathleen Concannon, MPH; Zintars Beldavs, MS; Margaret Cunningham, MPH; P. Maureen Cassidy, MPH; Erin C. Phipps, DVM, MPH; Nicole Kenslow, MPH; Tatiana Travis, BS; David Lonsway, MMS; J. Kamile Rasheed, PhD; Brandi M. Limbago, PhD; Alexander J. Kallen, MD, MPH

Importance  Carbapenem-resistant Enterobacteriaceae (CRE) are increasingly reported worldwide as a cause of infections with high-mortality rates. Assessment of the US epidemiology of CRE is needed to inform national prevention efforts.

Objective  To determine the population-based CRE incidence and describe the characteristics and resistance mechanism associated with ...

Viewpoint  FREE
Manisha Juthani-Mehta, MD; Preeti N. Malani, MD, MSJ; Susan L. Mitchell, MD, MPH

This Viewpoint discusses the risks and benefits of antimicrobial use, an approach to decision making in prescribing antimicrobials, and the next steps in improving infection management for patients at the end of life.

Viewpoint  FREE
Albert L. Siu, MD, MSPH; Kirsten Bibbins-Domingo, PhD, MD; David Grossman, MD, MPH
Medical News & Perspectives  FREE
Julie A. Jacob, MA

This Medical News & Perspectives article takes a look at a recent study that found an association between a Lactobacillus-poor vaginal microbiome and the risk of preterm birth.

Aaron S. Kesselheim, MD, JD, MPH; Lara R. Maggs, MBioethics; Ameet Sarpatwari, JD, PhD
Includes: Supplemental Content

This Viewpoint assesses the US Food and Drug Administration’s priority review voucher program to encourage development of drugs to treat neglected tropical diseases or rare pediatric disease and recommends improvements to the program.

Anne R. Cappola, MD, ScM; Garret A. FitzGerald, MD, FRS

This Viewpoint discusses themes that emerged at the recent Institute for Translational Medicine and Therapeutics international meeting on conflict of interest.

Dave A. Chokshi, MD, MSc; Abdulrahman M. El-Sayed, MD, DPhil; Nicholas W. Stine, MD

This Viewpoint discusses approaches to public health communication challenges posed by J-shaped associations between health effects and major modifiable risk factors.

Joanne Lynn, MD, MA, MS; Aaron McKethan, PhD; Ashish K. Jha, MD, MPH

This Viewpoint emphasizes the inclusion of actual patient values in developing an effective value-based payment system.

William A. Gahl, MD, PhD; Anastasia L. Wise, PhD; Euan A. Ashley, MRCP, DPhil

This Viewpoint discusses the launch of the Undiagnosed Diseases Network and its features.

Viewpoint  FREE
Joshua M. Sharfstein, MD; Alta Charo, JD

This Viewpoint expresses concern over recent court-established First Amendment rights applications to the US FDA’s drug approval process.

Comment & Response  FREE
Anna A. Ahimastos, PhD; Christopher Askew, PhD; Anthony Leicht, PhD; Elise Pappas, BSp, ExSc; Peter Blombery, MBBS, FRACP; Christopher M. Reid, PhD; Jonathan Golledge, MBBChir, MChir; Bronwyn A. Kingwell, PhD

To the Editor We wish to retract the article “Effect of Ramipril on Walking Times and Quality of Life Among Patients with Peripheral Artery Disease and Intermittent Claudication: A Randomized Controlled Trial,” published in the February 6, 2013, issue of JAMA.1 A recent internal subanalysis of ...

Viewpoint  FREE
Thomas F. Boat, MD; Stephen L. Buka, ScD; James M. Perrin, MD

This Viewpoint discusses the numbers of children living in poverty and receiving benefits for mental disabilities and potential considerations for improvement of the Supplemental Security Income program for children with mental disorders.

Viewpoint  FREE
Harvey G. Klein, MD; Willy A. Flegel, MD; Charles Natanson, MD

This Viewpoint discusses how new technologies could be developed and applied to the decision to transfuse.

Viewpoint  FREE
Yael Schenker, MD, MAS; Robert Arnold, MD

This Viewpoint urges the development of systems to help patients with serious illness and their families understand palliative care options.

Topics: palliative care
Viewpoint  FREE
Philip Rocco, PhD; Walid F. Gellad, MD, MPH; Julie M. Donohue, PhD

This Viewpoint discusses CMS’ proposed overhaul of Medicaid’s managed care programs.

Viewpoint  FREE
Mitchell W. Krucoff, MD; Art Sedrakyan, MD, PhD; Sharon-Lise T. Normand, PhD
Includes: Supplemental Content

This Viewpoint proposes implementation of strategic coordinated registries networks as the foundation for a national surveillance system that inform decisions about medical device safety, effectiveness, and quality.

Viewpoint  FREE
Jing Luo, MD; Aaron S. Kesselheim, MD, JD, MPH

This Viewpoint discusses the importance of patent protection and its role in the Trans-Pacific Partnership (TPP) Agreement.

Viewpoint  FREE
Arthur L. Kellermann, MD, MPH; Nihar R. Desai, MD, MPH

This Viewpoint discusses obstacles and policy options for the development and adoption of cost-lowering health technologies in the United States.

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