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Original Investigation | February 2, 2016 CME

Subcutaneous Treatment for Chronic Sinusitis With Nasal Polyposis

This randomized trial compares the effects of adding dupilumab, an IL-4 and IL-13 signaling inhibitor, to mometasone furoate nasal spray vs mometasone alone in adults with chronic sinusitis and nasal polyposis refractory to intranasal corticosteroids.

Featured article

Original Investigation | February 2, 2016

Acetazolamide and Duration of Invasive Mechanical Ventilation

This randomized clinical trial assesses whether acetazolamide reduces mechanical ventilation duration among critically ill patients with chronic obstructive pulmonary disease and metabolic alkalosis.

Featured article

Original Investigation | February 2, 2016 CME

Seafood Consumption, Mercury, and Brain Neuropathology in Older Adults

This cohort study describes correlations and associations between premortem seafood intake, postmortem brain mercury levels, and postmortem Alzheimer disease neuropathology in older adults.


Featured article

Viewpoint | February 4, 2016 FREE ONLINE FIRST

Oregon’s Medicaid Coordinated Care Organizations

This Viewpoint describes steps taken by Oregon to change its Medicaid program to improve health care access and population health and slow increases in spending.

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Viewpoint | February 1, 2016 FREE ONLINE FIRST

Affordable Care Act and Contraceptive Coverage

This Viewpoint discusses the barriers women face in realizing full benefits of the Affordable Care Act’s no co-pay contraceptive coverage guarantee.

Clinical Review & Education

Featured article

From The Medical Letter on Drugs and Therapeutics | February 2, 2016

Drugs Past Their Expiration Date

This Medical Letter review summarizes findings regarding the safety of use of drugs past their expiration date in the United States.

Explore more articles:  Current Issue | Online First

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Author Interview

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Interview with Martha Clare Morris, ScD, author of Association of Seafood Consumption, Brain Mercury Level, and APOE ε4 Status With Brain Neuropathology in Older Adults

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Association of Seafood Consumption, Brain Mercury Level, and APOE ε4 Status With Brain Neuropathology in Older Adults

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Article Video

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Neurologic Examination of a Patient With Suspected Distal Symmetric ... (7:43)

Video demonstration of the neurologic examination of a patient with suspected distal symmetric polyneuropathy.

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JAMA Editor's Audio Summary

February 2, 2016

Dupilumab for chronic sinusitis, effects of acetazolamide on COPD ventilation duration, seafood intake and dementia, and more.

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Author Readings
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Reading by Graham McMahon, author of Advancing Continuing Medical Education

Latest Quiz

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Well-Demarcated, Scaly Plaques

A 46-year-old woman presented with well-demarcated erythematous scaly plaques, with central clearing, on her chest, back, flanks, and groin. She reported that the eruption worsens with warmer weather but reported no other pain or rash.

What would you do next?

From The JAMA Network

Transcranial Magnetic Stimulation for Chronic Tinnitus

JAMA Patient Page

For your patients: Dietary Guidelines for Americans.

Past JAMA Patient Pages are available in English and Spanish.

A Piece of My Mind

My Body, Your Crime

JAMA Medical Student Elective in Medical Editing

JAMA offers a 4-week elective in medical editing to third- and fourth-year US medical students. The elective is full-time and must be taken for academic credit. For information and an application, please e-mail jamams@jamanetwork.org.

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Medical News

US Infant Mortality Rate Declines but Still Exceeds Other Developed Countries

Visualizing Health Policy

When and Why People Die in the United States, 1990-2013

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