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April 16, 2014
Vol 311, No. 15
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Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors vs Conventional Chemotherapy in Non–Small Cell Lung Cancer Harboring Wild-Type Epidermal Growth Factor Receptor: A Meta-analysis. Lee et al.

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Evidentiary Rationales for the Choosing Wisely Top 5 Lists. Gliwa and Pearson.

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A Systematic Assessment of Benefits and Risks to Guide Breast Cancer Screening Decisions. Pace and Keating.

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Research

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Randomized Comparison of Transcatheter Aortic Valves

     This randomized trial reports greater device success with balloon-expandable compared to self-expandable transcatheter aortic valve in symptomatic patients older than 75 years with severe aortic stenosis.

Editorial: Choice of Valves for TAVR

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Maternal Body Mass Index and Adverse Fetal Outcomes

     This meta-analysis reports an association between increases in maternal BMI and increases in adverse fetal outcomes, including fetal death, stillbirth, and infant death.

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The Changing Legal Climate for Physician Aid in Dying

     This Viewpoint describes the change in legal climate supporting physician aid in dying (physician-assisted suicide) and the reasons underlying the change.

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Health Reform and Physician-Led Accountable Care

     This Viewpoint argues that physician-led accountable care organizations that leverage the insights of primary care physicians can be a key driver of health care reform.

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Overcoming Barriers to the Conduct of Large, Simple Trials

     This Viewpoint discusses barriers and underleveraged opportunities to develop efficient clinical trials that use adequate samples sizes to determine the effects of interventions on clinically meaningful outcomes at an affordable cost.

Clinical Review & Education

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Fibromyalgia  FREE  CME

     This narrative review summarizes the epidemiology, pathophysiology, diagnosis, and treatment of fibromyalgia.

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Researchers Test Strategies to Prevent Alzheimer Disease

     This news feature reports on recent efforts to develop and test therapies to delay or prevent the onset of Alzheimer disease in cognitively healthy at-risk volunteers.

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Health Reform and Health Care Access

Medicaid Expansion: Practical and Political Considerations

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Invited Commentary: Calling All Doctors

Expansions in State Medicaid and Access to Care  ONLINE FIRST

Uninsured Low-Income Adults and State Medicaid Expansion  ONLINE FIRST

Editorial: Health Insurance Is Not Health Care

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Author Interview

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Interview with Mohamed Abdel-Wahab, MD, author of Comparison of Balloon-Expandable vs Self-expandable Valves in Patients Undergoing Transcatheter Aortic Valve Replacement: The CHOICE Randomized Clinical Trial

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Comparison of Balloon-Expandable vs Self-expandable Valves in Patients Undergoing Transcatheter Aortic Valve Replacement:  The CHOICE Randomized Clinical Trial

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Neurological Assessment of Case Patients 1 and 2 (04:18)

Case 1, a patient with essential tremor; and case 2, a patient with tremor-dominant Parkinson disease before and after unilateral thalamic deep brain stimulation.


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Waxman Leaves a Mark on Health Policy

During his 20 terms in Congress, Rep Henry Waxman (D, Calif) has had a major influence on US health policy. This timeline highlights many laws he helped shape and how they've changed the US health care system.


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JAMA Editor's Audio Summary

April 15, 2014

JAMA: 2014-04-15, Vol. 311, No. 15,
Editor's Audio Summary

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Reading by David G. Stevenson, PhD, author of Integrating Care at the End of Life: Should Medicare Advantage Include Hospice?


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A Nodular Protuberance on the Hard Palate

A 66-year-old man presents with a slowly enlarging growth in his mouth that appeared more than 20 years ago. He denies pain and discomfort but is concerned because the mass has increased in size during the past year.

What would you do next?

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Parental Perspectives on Adolescent Hearing Loss

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For your patients: Fibromyalgia.

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Cost-Related Motivations for Conducting Research

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JAMA Medical Student Elective in Medical Editing

JAMA offers a 4-week elective in medical editing to third- and fourth-year US medical students. The elective is full-time and must be taken for academic credit. For information and an application, please e-mail jamams@jamanetwork.org.

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David G. Stevenson, PhD, reads his Viewpoint, Integrating Care at the End of Life

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CDC: Hospital Antibiotic Use Promotes Resistance

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What Americans Pay for Health Insurance Under the ACA

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Fibromyalgia

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