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Credit: Steve Villano,
Shire PLC.

Original Investigation | May 5, 2015

Nontoxigenic Clostridium difficile for Prevention of Recurrent Infection

This phase 2 randomized trial reports that spores of nontoxigenic Clostridium difficile strain M3 were well tolerated, appeared to be safe, and reduced recurrence of C difficile infection.
Author Video Interview   |   JAMA Report Video

Featured article

Original Investigations | May 5, 2015

Oral Antiviral Treatment of Hepatitis C Genotype 1 Infection

These cohort studies describe outcomes for HCV genotype-1 infected patients with and without cirrhosis who were treated with an all-oral antiviral regimen.
Daclatasvir, Asunaprevir, and Beclabuvir for HCV Genotype 1
DCV/ASV/BCV for HCV Infection With Cirrhosis
Editorial: Continued Progress Against Hepatitis C Infection

Featured article

Original Investigation | May 4, 2015 FREE ONLINE FIRST

Outcomes for ACOs vs Traditional Medicare Fee for Service

This study compares health care spending, utilization, and patient experiences among fee-for-service Medicare beneficiaries cared for by physicians participating in CMS’ Pioneer Accountable Care Organization Model and those cared for through the traditional Medicare program.
Editorial: Pioneer Accountable Care Organizations
Editorial: Evidence-Based Payment Reform

Clinical Review & Education

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Special Communication | April 28, 2015 FREE ONLINE FIRST

PRISMA Extension for Individual Patient Data

This extension of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline provides additional guidance for reporting meta-analyses based on individual patient data.


Featured article

Viewpoint | April 30, 2015 FREE ONLINE FIRST

The Precision Medicine Initiative

This Viewpoint discusses the distinction between personalized and precision medicine and the roles the US initiative can play in addressing unmet needs and remaining challenges.

Featured article

Viewpoint | April 28, 2015 FREE ONLINE FIRST

IOM Report on Core Metrics for Health and Health Care

This Viewpoint discusses an Institute of Medicine report that identifies 15 measures as core metrics for better health at lower cost.

Featured article

Viewpoint | April 28, 2015 ONLINE FIRST

Induced Pluripotent Stem Cells

This Viewpoint reviews the role induced pluripotent stem cells could play in disease modeling, drug discovery, and personalized medicine.

Medical News & Perspectives

Featured article

Medical News & Perspectives | April 27, 2015 FREE ONLINE FIRST

Being "Nimble and Flexible" Is New Surgeon General's Goal

Newly inducted US Surgeon General Vivek Murthy tells JAMA about his path to the role of “America’s doctor” and his vision for the health of the nation.
Related: A To-Do List for the Next US Surgeon General

Featured article

Medical News & Perspectives | April 22, 2015 FREE ONLINE FIRST

Florida Legislation Casts a Chill Over Gun Inquiries

This Medical News feature summarizes the legal and practical questions that surround a 2011 Florida law discouraging physicians from routinely asking about gun ownership.
Firearm-Related Hospitalizations: 20 US Children, Teens Daily
States Take a Public Health Approach to Curb Gun Violence
Scientific Publications on Firearms in Youth
Silencing the Science on Gun Research

Explore more articles:  Current Issue | Online First

Multimedia >

Author Interview

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Interview with Andrew J. Muir, MD, author of Daclatasvir in Combination With Asunaprevir and Beclabuvir for Hepatitis C Virus Genotype 1 Infection With Compensated Cirrhosis

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Daclatasvir in Combination With Asunaprevir and Beclabuvir for Hepatitis C Virus Genotype 1 Infection With Compensated Cirrhosis

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Article Video

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Video Summary: Medical Applications of 3D Printing Technologies (3:53)

Mark H. Michalski, MD, explains 3D printing and describes the application of this technology in clinical medicine, education, and patient communication.

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Interactive preview

Video Clip of Patient’s Echocardiogram and Doppler Tracing Through the ...

This interactive includes Doppler echocardiography findings from a patient with a heart murmur. How do you interpret these test results?

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Author Readings
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Reading by Timothy Jost, JD, author of An Affordable Care Act at Year 5: Key Issues for Improvement

Latest Quiz

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Tattoo Rash

A previously healthy 32-year-old man presented with 27-kg weight loss over the course of 1 year, dyspnea, nonproductive cough, subjective fevers, night sweats, and painful hematuria.

What would you do next?

From The JAMA Network

Ramelteon for Prevention of Delirium in Hospitalized Older Patients

JAMA Patient Page
Male Infertility

For your patients: Male Infertility.

Past JAMA Patient Pages are available in English and Spanish.

A Piece of My Mind

The Hero in Medicine

JAMA Medical Student Elective in Medical Editing

JAMA offers a 4-week elective in medical editing to third- and fourth-year US medical students. The elective is full-time and must be taken for academic credit. For information and an application, please e-mail jamams@jamanetwork.org.

Video Translations

International translations of Author Video Interviews

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Medical News

Unraveling the Influence of Gut Microbes on the Mind

Visualizing Health Policy

Premium Changes in the Affordable Care Act's Health Insurance Marketplaces, 2014-2015

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Physician Jobs