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Since 1883, physicians and health care professionals around the world have turned to JAMA for groundbreaking research and insightful commentary from leaders across the broad spectrum of health care. Subscribe/Learn More

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Original Investigation | December 1, 2015 CME  audio icon

Metformin for Adolescents With Type 1 Diabetes

This randomized trial reports that the addition of metformin to insulin does not improve glycemic control in overweight adolescents with type 1 diabetes and increases incidence of gastrointestinal adverse events.

Featured article

Original Investigation | December 1, 2015

Vericiguat and Worsening Chronic Heart Failure

This phase 2 study investigates the optimal dose and tolerability of vericiguat, a soluble guanylate cyclase stimulator, in patients with worsening chronic heart failure with reduced left ventricular ejection fraction.
Related: Dose-Finding Trials

Featured article

Original Investigation | December 1, 2015

Treatment for Obstructive Sleep Apnea

This meta-analysis of trials comparing treatments for obstructive sleep apnea investigates associations between continuous positive airway pressure vs mandibular advancement devices and change in blood pressure.

Clinical Review & Education

Featured article

JAMA Guide to Statistics and Methods | December 1, 2015

Dose-Finding Trials

This Guide to Statistics and Methods discusses the use of dose-response models in phase 2 studies for identifying promising doses to use in further development of a new drug.
Related: Phase 2 Trial of Vericiguat for Heart Failure

Featured article

From The Medical Letter on Drugs and Therapeutics | December 1, 2015

Evolocumab (PCSK9 Inhibitor) for Cholesterol Lowering

This Medical Letter review summarizes the PCSK9 inhibitor evolocumab prescribed as an adjunct to statins and diet in the treatment of hypercholesterolemia.
Patient Information


Viewpoint | November 30, 2015 FREE ONLINE FIRST

Steps to Support Value-Based Pricing for Drugs

This Viewpoint proposes policy options for payers and the federal government to incentivize pharmaceutical manufacturers to adopt value-based pricing of prescription drugs commensurate with the value they bring to patients.

Featured article

Viewpoint | November 23, 2015 FREE ONLINE FIRST

Stakeholder-Driven Comparative Effectiveness Research

This Viewpoint describes how patient, caregiver, clinician, researcher, payer, and industry stakeholders help the Patient-Centered Outcomes Research Institute (PCORI) develop research questions, review research applications, and conduct research.

Medical News & Perspectives

Featured article

Medical News & Perspectives | November 25, 2015 FREE ONLINE FIRST

New Approaches to Mitigating Cognitive Decline

This Medical News and Perspectives article explores the biological mechanisms underlying brain resilience that could help inform therapeutic strategies to mitigate cognitive decline.

Explore more articles:  Current Issue | Online First

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Author Interview

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Interview with Ingrid M. Libman, MD, PhD, author of Effect of Metformin Added to Insulin on Glycemic Control Among Overweight/Obese Adolescents With Type 1 Diabetes

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Effect of Metformin Added to Insulin on Glycemic Control Among Overweight/Obese Adolescents With Type 1 Diabetes A Randomized Clinical Trial

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Article Video

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Neurologic Examination of a Patient With Suspected Distal Symmetric ... (7:43)

Video demonstration of the neurologic examination of a patient with suspected distal symmetric polyneuropathy.

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JAMA Editor's Audio Summary

December 1, 2015

Metformin for type 1 diabetes in obese adolescents, c-section deliveries and maternal-child outcomes, effect of OSA treatments on blood pressure, and more.

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Author Readings
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Reading by Graham McMahon, author of Advancing Continuing Medical Education

Latest Quiz

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Widespread Scaly Eruption in a Patient With Multiple Comorbidities

A 73-year-old woman presented with a widespread scaly pruritic rash lasting 2 months. She had an antinuclear antibody titer of 1:80, elevated SS-A antibodies, a creatinine level of 1.8 mg/dL, and an inflammatory pattern on skin biopsy.

What would you do next?

From The JAMA Network

Doing Less Is Sometimes Enough

JAMA Patient Page

For your patients: PCSK9 Inhibitors for Treating High Cholesterol.

Past JAMA Patient Pages are available in English and Spanish.

A Piece of My Mind

Every Little Anniversary

JAMA Medical Student Elective in Medical Editing

JAMA offers a 4-week elective in medical editing to third- and fourth-year US medical students. The elective is full-time and must be taken for academic credit. For information and an application, please e-mail jamams@jamanetwork.org.

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Medical News

Increasing the Number of Black Men Entering Medical School

Visualizing Health Metrics

Cardiovascular Disease Worldwide, 1990-2013

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Physician Jobs