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Since 1883, physicians and health care professionals around the world have turned to JAMA for groundbreaking research and insightful commentary from leaders across the broad spectrum of health care. Subscribe/Learn More

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Featured article

Original Investigation | August 30, 2015 FREE ONLINE FIRST

CHA2DS2-VASc Accuracy for Predicting Heart Failure Outcomes

This cohort study assessed the accuracy of the CHA2DS2-VASc score for predicting ischemic stroke, thromboembolism, and death in patients with heart failure with and without atrial fibrillation.

Featured article

August 25, 2015

Lifestyle and Cognitive Health in Older Adults

These randomized trials evaluate the effects of physical activity and dietary supplements on cognitive function in older adults.

Activity Intervention vs Health Education in Sedentary Older Adults

Effect of Nutrient Supplementation on Cognitive Function

Editorial: Optimizing Cognitive Health in Older Individuals

Featured article

Original Investigation | August 25, 2015

Time to Epinephrine After Pediatric In-Hospital Cardiac Arrest

This study uses data for pediatric patients from the Get With the Guidelines–Resuscitation registry to report associations between delay in epinephrine and survival and neurological outcome after pediatric in-hospital cardiac arrest.

Featured article

Preliminary Communication | August 25, 2015 ONLINE FIRST

Mutation Clearance After Chemotherapy and Outcomes in AML

This cohort study investigates clearance patterns of somatic mutations in acute myeloid leukemia patients given induction chemotherapy, and associations between those patterns and clinical outcomes.

Clinical Review & Education

Featured article

Review | August 18, 2015 CME

Septic Shock: Advances in Diagnosis and Treatment

This narrative review summarizes advances in the diagnosis and treatment of septic shock between 2010-2015.

Featured article

JAMA Clinical Evidence Synopsis | August 18, 2015

Isotonic vs Hypotonic Intravenous Fluids for Hospitalized Children

This Clinical Evidence Synopsis summarizes a recent Cochrane Review comparing the risk of hyponatremia with isotonic vs hypotonic intravenous fluid for maintenance hydration in children.

Featured article

From The Medical Letter on Drugs and Therapeutics | August 18, 2015

Sacubitril/Valsartan (Entresto) for Heart Failure

This Medical Letter on Drugs and Therapeutics article provides information about sacubitril/valsartan, a recently approved fixed-dose combination medication for patients with heart failure and reduced ejection fraction.


Featured article

Viewpoint | August 20, 2015 FREE ONLINE FIRST

The TPP Agreement and Implications for Access to Essential Medicines

This Viewpoint discusses the importance of US intellectual property law to the goals of rewarding innovation and increasing global access to drugs within the context of the Trans-Pacific Partnership (TPP) Agreement.

Featured article

Viewpoint | August 18, 2015

Costs Associated With Using Different Insulin Preparations

This Viewpoint summarizes available insulin treatment regimens and the rationale for using each and proposes that treatment cost should be a factor in choosing which to use.

Featured article

Viewpoint | August 17, 2015 FREE ONLINE FIRST

Obstacles to Developing Cost-Lowering Health Technology

This Viewpoint discusses obstacles and policy options for the development and adoption of cost-lowering health technologies in the United States.

Medical News & Perspectives

Featured article

Medical News & Perspectives | August 19, 2015 FREE ONLINE FIRST

The Future of AHRQ’s Health Services Research

In this Medical News and Perspectives interview, Richard Kronick, PhD, Director of the Agency for Healthcare Research and Quality, discusses the mission of the agency and its relationship with other federal health research entities.

Explore more articles:  Current Issue | Online First

Multimedia >

Author Interview

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Interview with Timothy Ley, MDr, author of Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia

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Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia

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Article Video

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Video 1. Ambulation Mode Transitions Using a Powered Prosthetic Leg ... (02:11)

This video shows transitions between ambulation modes controlled by the experimenter during control system training.

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Interactive preview

Video Clip of Patient’s Echocardiogram and Doppler Tracing Through the ...

This interactive includes Doppler echocardiography findings from a patient with a heart murmur. How do you interpret these test results?

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JAMA Editor's Audio Summary

August 25, 2015

Effects of exercise and supplements on cognition in older adults, mutation clearance and AML outcomes, and more.

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Author Readings
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Reading by Graham McMahon, author of Advancing Continuing Medical Education

Latest Quiz

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Fatigue and an Elevated White Blood Cell Count

A 67-year-old woman presented with fatigue for 4 weeks. She had a history of type 2 diabetes mellitus, hypertension, hyperlipidemia, and allergic rhinitis. Her medications included metformin, lisinopril, and verapamil.

What would you do next?

From The JAMA Network

Engaging Primary Care Clinicians in Early Obesity Prevention Research

JAMA Patient Page

For your patients: Childhood Obesity.

Past JAMA Patient Pages are available in English and Spanish.

A Piece of My Mind

The “Good Person” Sign

JAMA Medical Student Elective in Medical Editing

JAMA offers a 4-week elective in medical editing to third- and fourth-year US medical students. The elective is full-time and must be taken for academic credit. For information and an application, please e-mail jamams@jamanetwork.org.

Video Translations

International translations of Author Video Interviews

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Medical News

Safety and Fairness in the Right-to-Try

Visualizing Health Policy

Medicaid and Medicare at 50

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Physician Jobs