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IN THIS ISSUE

JAMA: The Journal of the American Medical Association

March 19, 2008, Vol 299, No. 11
Theme: Genetics/Genomics
Basic View  |  Expanded View
My Father
Robert S. Bobrow, MD
Topics:
JAMA. 2008;299(11):1235-1236.  doi: 10.1001/jama.299.11.1235
Relationship of Paraoxonase 1 (PON1) Gene Polymorphisms and Functional Activity With Systemic Oxidative Stress and Cardiovascular Risk FREE
Tamali Bhattacharyya, MD, MS; Stephen J. Nicholls, MBBS, PhD; Eric J. Topol, MD; Renliang Zhang, MD, PhD; Xia Yang, PhD; David Schmitt, BA; Xiaoming Fu, MS; Mingyuan Shao, MS; Danielle M. Brennan, MS; Stephen G. Ellis, MD; Marie-Luise Brennan, PhD; Hooman Allayee, PhD; Aldons J. Lusis, PhD; Stanley L. Hazen, MD, PhD
Topics: oxidative stress, cardiovascular diseases, cardiovascular disease risk factors, polymorphism, genotype, aryldialkylphosphatase, pon1 gene
JAMA. 2008;299(11):1265-1276.  doi: 10.1001/jama.299.11.1265
Large-Scale Analysis of Association Between LRP5 and LRP6 Variants and Osteoporosis FREE
Joyce B. J. van Meurs, PhD; Thomas A. Trikalinos, MD; Stuart H. Ralston, MD; Susana Balcells, PhD; Maria Luisa Brandi, MD, PhD; Kim Brixen, MD, PhD; Douglas P. Kiel, MD, PhD; Bente L. Langdahl, MD; Paul Lips, MD, PhD; Östen Ljunggren, MD, PhD; Roman Lorenc, MD, PhD; Barbara Obermayer-Pietsch, MD, PhD; Claes Ohlsson, MD, PhD; Ulrika Pettersson, MD, PhD; David M. Reid, MD; Francois Rousseau, MD; Serena Scollen, BSc; Wim Van Hul, PhD; Lidia Agueda, BSc; Kristina Åkesson, MD, PhD; Lidia I. Benevolenskaya, MD; Serge L. Ferrari, MD; Göran Hallmans, MD, PhD; Albert Hofman, MD, PhD; Lise Bjerre Husted, PhD; Marcin Kruk, PhD; Stephen Kaptoge, PhD; David Karasik, PhD; Magnus K. Karlsson, MD, PhD; Mattias Lorentzon, MD, PhD; Laura Masi, MD, PhD; Fiona E. A. McGuigan, PhD; Dan Mellström, MD, PhD; Leif Mosekilde, MD; Xavier Nogues, MD, PhD; Huibert A. P. Pols, MD, PhD; Jonathan Reeve, MD; Wilfried Renner, PhD; Fernando Rivadeneira, MD, PhD; Natasja M. van Schoor, PhD; Kurt Weber, MD; John P. A. Ioannidis, MD; André G. Uitterlinden, PhD; for the GENOMOS Study
Includes: Supplemental Content
Topics: alleles, osteoporosis, polymorphism, fracture, neck of femur, lumbar vertebra, spinal fractures
JAMA. 2008;299(11):1277-1290.  doi: 10.1001/jama.299.11.1277
Association of FKBP5 Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder Symptoms in Adults FREE
Elisabeth B. Binder, MD, PhD; Rebekah G. Bradley, PhD; Wei Liu, PhD; Michael P. Epstein, PhD; Todd C. Deveau, BS; Kristina B. Mercer, MPH; Yilang Tang, MD, PhD; Charles F. Gillespie, MD, PhD; Christine M. Heim, PhD; Charles B. Nemeroff, MD, PhD; Ann C. Schwartz, MD; Joseph F. Cubells, MD, PhD; Kerry J. Ressler, MD, PhD
Topics: polymorphism, genotype, single nucleotide polymorphism, post-traumatic stress disorder, wounds and injuries, child abuse, science of genetics, fkbp5 gene
JAMA. 2008;299(11):1291-1305.  doi: 10.1001/jama.299.11.1291
Gene Variants Associated With Deep Vein Thrombosis FREE
Irene D. Bezemer, MSc; Lance A. Bare, PhD; Carine J. M. Doggen, PhD; Andre R. Arellano, BS; Carmen Tong, BS; Charles M. Rowland, MS; Joseph Catanese, BS; Bradford A. Young, PhD; Pieter H. Reitsma, PhD; James J. Devlin, PhD; Frits R. Rosendaal, MD, PhD
Includes: Supplemental Content
Topics: deep vein thrombosis, fibronectins, genes, single nucleotide polymorphism
JAMA. 2008;299(11):1306-1314.  doi: 10.1001/jama.299.11.1306
F18-Fluorodeoxyglucose–Positron Emission Tomography/Computed Tomography Screening in Li-Fraumeni Syndrome FREE
Serena Masciari, MD; Annick D. Van den Abbeele, MD; Lisa R. Diller, MD; Iryna Rastarhuyeva, MD; Jeffrey Yap, PhD; Katherine Schneider, MPH; Lisa Digianni, PhD; Frederick P. Li, MD; Joseph F. Fraumeni, MD; Sapna Syngal, MD, MPH; Judy E. Garber, MD, MPH
Topics: positron-emission tomography, computed tomography, cancer, li-fraumeni syndrome, diagnostic imaging, fluorodeoxyglucose positron emission tomography
JAMA. 2008;299(11):1315-1319.  doi: 10.1001/jama.299.11.1315
Clinician's Corner
Delivery of Genomic Medicine for Common Chronic Adult Diseases: Title and subTitle BreakA Systematic Review FREE
Maren T. Scheuner, MD, MPH; Pauline Sieverding, MPA, JD, PhD; Paul G. Shekelle, MD, PhD
Includes: CME
Topics: cancer, chronic disease, science of genetics, genomic medicine, genetic screening
JAMA. 2008;299(11):1320-1334.  doi: 10.1001/jama.299.11.1320
How to Interpret a Genome-wide Association Study
Thomas A. Pearson, MD, MPH, PhD; Teri A. Manolio, MD, PhD
Topics: single nucleotide polymorphism, science of genetics, genotype determination, genome-wide association study
JAMA. 2008;299(11):1335-1344.  doi: 10.1001/jama.299.11.1335
Epigenetics at the Epicenter of Modern Medicine
Andrew P. Feinberg, MD, MPH
Topics: epigenetics
JAMA. 2008;299(11):1345-1350.  doi: 10.1001/jama.299.11.1345
The Genome Gets Personal—Almost
W. Gregory Feero, MD, PhD; Alan E. Guttmacher, MD; Francis S. Collins, MD, PhD
Topics: genome
JAMA. 2008;299(11):1351-1352.  doi: 10.1001/jama.299.11.1351
Genomic Profiles for Disease Risk: Title and subTitle BreakPredictive or Premature?
Kenneth Offit, MD, MPH
Topics: genome, genetic screening
JAMA. 2008;299(11):1353-1355.  doi: 10.1001/jama.299.11.1353
Key Internet Genetics Resources for the Clinician
Wendy R. Uhlmann, MS, CGC; Alan E. Guttmacher, MD
Topics: internet, science of genetics, genetic screening
JAMA. 2008;299(11):1356-1358.  doi: 10.1001/jama.299.11.1356
Centralized Biorepositories for Genetic and Genomic Research
Geoffrey S. Ginsburg, MD, PhD; Thomas W. Burke, PhD; Phillip Febbo, MD
Topics: genome, science of genetics
JAMA. 2008;299(11):1359-1361.  doi: 10.1001/jama.299.11.1359
Gene Discovery in Venous Thrombosis: Title and subTitle BreakProgress and Promise
Edwin G. Bovill, MD
Topics: venous thrombosis, genes
JAMA. 2008;299(11):1362-1363.  doi: 10.1001/jama.299.11.1362
Genetics and Genomics for Clinicians
Phil B. Fontanarosa, MD, MBA; Boris Pasche, MD, PhD; Catherine D. DeAngelis, MD, MPH
Topics: genomics, science of genetics
JAMA. 2008;299(11):1364-1365.  doi: 10.1001/jama.299.11.1364
Health Research and the HIPAA Privacy Rule
Samuel J. Tilden, MD, JD, LLM
Topics:
JAMA. 2008;299(11):1259-1260.  doi: 10.1001/jama.299.11.1259-a
Health Research and the HIPAA Privacy Rule—Reply
Robert J. Levine, MD; Norman Fost, MD, MPH
Topics:
JAMA. 2008;299(11):1259-1260.  doi: 10.1001/jama.299.11.1260-b
Health Research and the HIPAA Privacy Rule—Reply
Roberta B. Ness, MD, MPH
Topics:
JAMA. 2008;299(11):1259-1260.  doi: 10.1001/jama.299.11.1260-a
Cardiovascular Risk Factors, Mortality, and Overweight
Kathleen McTigue, MD, MS, MPH; Lewis Kuller, MD, DrPH
Topics:
JAMA. 2008;299(11):1260-1261.  doi: 10.1001/jama.299.11.1260-c
Cardiovascular Risk Factors, Mortality, and Overweight—Reply
Katherine M. Flegal, PhD; Barry I. Graubard, PhD; David F. Williamson, PhD; Mitchell H. Gail, MD, PhD
Topics:
JAMA. 2008;299(11):1260-1261.  doi: 10.1001/jama.299.11.1261-a
Metabolic Responses to Reduced Daily Steps in Healthy Nonexercising Men
Topics:
JAMA. 2008;299(11):1261-1263.  doi: 10.1001/jama.299.11.1259
New Screening Tool Reveals Genes Essential for Cancer Cells’ Survival
Tracy Hampton, PhD
Topics: cancer, genes, tumor cells, malignant
JAMA. 2008;299(11):1247-1248.  doi: 10.1001/jama.299.11.1247
Randy L. Jirtle, PhD
Bridget M. Kuehn
Topics: genes, epigenetics
JAMA. 2008;299(11):1249-1250.  doi: 10.1001/jama.299.11.1249
Fat-Burning Gene
Joan Stephenson, PhD
Topics: genes, burning sensation
JAMA. 2008;299(11):1252-1252.  doi: 10.1001/jama.299.11.1252-c
Intellectual Disability
Joan Stephenson, PhD
Topics: intellectual disability
JAMA. 2008;299(11):1252-1252.  doi: 10.1001/jama.299.11.1252-a
Macular Degeneration
Joan Stephenson, PhD
Topics: macular degeneration
JAMA. 2008;299(11):1252-1252.  doi: 10.1001/jama.299.11.1252-d
Prostate Cancer Genes
Joan Stephenson, PhD
Topics: genes, prostate cancer
JAMA. 2008;299(11):1252-1252.  doi: 10.1001/jama.299.11.1252-b
Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction—Eight States, 1998-2005 FREE
Topics: pneumococcal infections, vaccines, conjugate, pneumococcal 7-valent conjugate vaccine, diplacusis
JAMA. 2008;299(11):1253-1255.  doi: 10.1001/jama.299.11.1253
Physical Activity Among Adults With a Disability—United States, 2005 FREE
Topics: physical activity, disability
JAMA. 2008;299(11):1255-1256.  doi: 10.1001/jama.299.11.1255
Double Portrait of Trudl
M. Therese Southgate, MD
Topics:
JAMA. 2008;299(11):1230-1230.  doi: 10.1001/jama.299.11.1230
Alone
Frank DeCicco, MD
Topics:
JAMA. 2008;299(11):1232-1232.  doi: 10.1001/jama.299.11.1232
HEREDITY AND TUBERCULOSIS.
Topics:
JAMA. 2008;299(11):1372-1372.  doi: 10.1001/jama.299.11.1372
About This Journal FREE
Topics:
JAMA. 2008;299(11):1227-1228.  doi: 10.1001/jama.299.11.1227
Researchers Create Artificial DNA Bases
Tracy Hampton, PhD
Topics: dna
JAMA. 2008;299(11):1251-1251.  doi: 10.1001/jama.299.11.1251
Principles of Developmental Genetics
Martin Cheung, PhD; Danny Chan, PhD
Topics:
JAMA. 2008;299(11):1366-1367.  doi: 10.1001/jama.299.11.1366
Gene Therapy
J. L. Mehta, MD, PhD
Topics:
JAMA. 2008;299(11):1367-1367.  doi: 10.1001/jama.299.11.1367-a
Gene Therapy for Cancer
Prem Seth, PhD
Topics:
JAMA. 2008;299(11):1367-1368.  doi: 10.1001/jama.299.11.1367-b
Babies by Design: The Ethics of Genetic Choice
Tony Miksanek, MD
Topics:
JAMA. 2008;299(11):1368-1369.  doi: 10.1001/jama.299.11.1368
Enhancing Evolution: The Ethical Case for Making Better People
John Collins Harvey, MD, PhD
Topics:
JAMA. 2008;299(11):1369-1370.  doi: 10.1001/jama.299.11.1369
The Ethics of Bioethics: Mapping the Moral Landscape
Alexander A. Kon, MD
Topics:
JAMA. 2008;299(11):1370-1371.  doi: 10.1001/jama.299.11.1370
Genetics: the Basics FREE
Janet M. Torpy, MD; Cassio Lynm, MA; Richard M. Glass, MD
Topics: genetic disorder, science of genetics
JAMA. 2008;299(11):1388-1388.  doi: 10.1001/jama.299.11.1388

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