TY - JOUR T1 - SCientists see promise and challenges in translating genomics to the clinic AU - Kuehn BM Y1 - 2011/04/06 N1 - 10.1001/jama.2011.376 JO - JAMA SP - 1285 EP - 1286 VL - 305 IS - 13 N2 - One of the first human beings to undergo whole-genome sequencing(Wheeler DA et al. Nature. 2008;45[7189]:872-876), Watson found that he carried a certain genetic variant that made him a slow metabolizer of the drug. So he and his physician reduced his dose, and he is now able to control his blood pressure without such adverse effects. SN - 0098-7484 M3 - doi: 10.1001/jama.2011.376 UR - http://dx.doi.org/10.1001/jama.2011.376 ER -