TY  - JOUR
T1  - MUcosal hiv protection
AU  - Hampton T
Y1  - 2011/04/06
N1  - 10.1001/jama.2011.385
JO  - JAMA
SP  - 1290
EP  - 1290
VL  - 305
IS  - 13
N2  - 
Acquisition of HIV through sexual intercourse mainly occurs at mucosal sites, but vaccine strategies under investigation usually aim to induce neutralizing antibodies or cytotoxic T cells circulating in the blood. An alternative vaccine strategy could be to elicit a mucosal immune response to block viral entry at mucosal sites. In this case, researchers sought to elicit IgA antibodies specific for gp41, HIV's most conserved envelope subunit. These antibodies have previously been shown to block HIV infection of mucosal cells.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2011.385
UR  - http://dx.doi.org/10.1001/jama.2011.385
ER  -