TY  - JOUR
T1  - STudy suggests gene may predict success of therapies for alcohol dependence
AU  - Kuehn BM
Y1  - 2011/03/09
N1  - 10.1001/jama.2011.270
JO  - JAMA
SP  - 984
EP  - 985
VL  - 305
IS  - 10
N2  - 
A growing body of data links variation in the μ-opioid receptors with an individual's response to alcohol. The findings also show a connection between such variation and a patient's response to treatment with naltrexone, a drug that targets these receptors. Additionally, basic studies have demonstrated that variations in the genes that encode serotonin transporters affect the response to alcohol. Now a randomized controlled trial has demonstrated that the latter variants can predict the response of alcohol-dependent patients to treatment with ondansetron, a drug used to treat chemotherapy-associated nausea that targets the serotonin receptors.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2011.270
UR  - http://dx.doi.org/10.1001/jama.2011.270
ER  -