TY  - JOUR
T1  - MAternal depression and child development after prenatal dha supplementation
AU  - Assies J, Mocking RT, Pouwer F
Y1  - 2011/01/26
N1  - 10.1001/jama.2011.18
JO  - JAMA
SP  - 359
EP  - 361
VL  - 305
IS  - 4
N2  - 
The absence of clear positive effects and the possible presence of negative effects in the children raise the question whether DHA supplementation is justifiable (not only during pregnancy, but in general). The answer depends on the interpretation of previously found low DHA in postpartum depression (and other pathophysiological states).2 Because association is not proof of causation, “low” levels may not necessarily mean “deficient” levels, but may represent adequate or even adaptive levels. Fatty acid status depends not only on dietary intake, but also on endogenous metabolism; eg, oxidative stress is associated with lower DHA levels.3 Lower levels of DHA may represent an adaptive process because cell membranes with less unsaturated fatty acids (such as DHA) are more resistant to oxidation.3

SN  - 0098-7484
M3  - doi: 10.1001/jama.2011.18
UR  - http://dx.doi.org/10.1001/jama.2011.18
ER  -