TY  - JOUR
T1  - BLood transfusion and cardiac surgery
AU  - McIlroy D, Argenziano M
Y1  - 2011/01/26
N1  - 10.1001/jama.2011.13
JO  - JAMA
SP  - 357
EP  - 359
VL  - 305
IS  - 4
N2  - 
The authors tested the hypothesis that a restrictive transfusion protocol would be noninferior to a more liberal transfusion protocol, setting an a priori noninferiority margin of −8% for their composite primary outcome of all-cause mortality and severe morbidity. Based on their stated assumption of a 10% incidence for the primary outcome (as was observed with the liberal transfusion algorithm), the study design requires accepting a primary event rate up to 18% in the restrictive transfusion group as representing equivalence between the 2 treatment groups.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2011.13
UR  - http://dx.doi.org/10.1001/jama.2011.13
ER  -