TY  - JOUR
T1  - EPithelioma as a sequel of psoriasis, and the probability of its arsenical origin.
Y1  - 1899/10/14
N1  - 10.1001/jama.1899.02450680057016
JO  - Journal of the American Medical Association
SP  - 989
EP  - 990
VL  - XXXIII
IS  - 16
N2  - There are recorded in medical literature a small number of cases of psoriasis treated for some time with arsenic and followed by the development of epithelioma. Hartzell1 has recently brought together the cases illustrating this sort of an apparent pathogenesis of carcinoma. The whole number of cases is small—only eleven; yet it is too large to permit the assumption that the association of psoriasis and carcinoma is purely accidental. It deserves special notice that in a large proportion of the cases—5 per cent.—the carcinoma appeared before 40 years of age, and that in the same proportion the carcinoma appeared as primarily multiple tumors. In eight of the cases the prolonged use of arsenic is recorded. The direct influence of the arsenic is strongly suggested by the fact that in eight of the eleven cases of psoriasis followed by epithelioma some form of keratosis preceded for a longer or shorter
SN  - 0002-9955
M3  - doi: 10.1001/jama.1899.02450680057016
UR  - http://dx.doi.org/10.1001/jama.1899.02450680057016
ER  -