TY - JOUR T1 - NEcrosis of the liver after chloroform anesthesia AU - Krone CR Y1 - 1909/06/12 N1 - 10.1001/jama.1909.02540500042016 JO - Journal of the American Medical Association SP - 1940 EP - 1940 VL - LII IS - 24 N2 - To the Editor:  —May I be permitted to comment on the conclusions reached by Drs. John R. Williams and W. D. Becker in their report of a case of "Necrosis of the Liver After Chloroform Anesthesia," The Journal for May 8, 1909, page 1488? Under title, "Postoperative History," a typical picture of the second stage of acute yellow atrophy of the liver is drawn. These second stage symptoms became rapidly deepened on the third day after operation and chloroform anesthesia, ending in death forty hours after the first indication of any mental disturbance.The history of the case points very clearly to a severe bacterial infection before the operation. We are shown a patient "subject to attacks of 'indigestion' from childhood." Turbid, dark-brown urine, of acid reaction, and showing albumin blood cells and hyalin casts found postmortem can be assumed to have been present four days before death at the SN - 0002-9955 M3 - doi: 10.1001/jama.1909.02540500042016 UR - http://dx.doi.org/10.1001/jama.1909.02540500042016 ER -