TY  - JOUR
T1  - CHolesterol and noncardiac mortality-reply
AU  - Smith G
Y1  - 1992/05/27
N1  - 10.1001/jama.1992.03480200048020
JO  - JAMA
SP  - 2741
EP  - 2741
VL  - 267
IS  - 20
N2  - In Reply. 
    —We disagree with Dr Goldstein's interpretation of our report regarding plasma cholesterol and mortality in the Whitehall Study.1 As we discussed, the increased noncardiovascular disease mortality among the men with low plasma cholesterol levels is likely to be due to two factors: (1) the illness existing at the time of screening is associated with low plasma cholesterol, and (2) the sociodemographic correlates of low plasma cholesterol are themselves associated with elevated mortality risk.A recent analysis of coronary heart disease primary prevention trials2 suggests that drug, but not dietary, lowering of plasma cholesterol is associated with increased noncardiovascular disease mortality. Thus, the cholesterol lowering itself is unlikely to be the culprit. Considerably more attention should be paid to the possibility that cholesterol-lowering drugs increase noncardiovascular disease mortality, however.
SN  - 0098-7484
M3  - doi: 10.1001/jama.1992.03480200048020
UR  - http://dx.doi.org/10.1001/jama.1992.03480200048020
ER  -