TY  - JOUR
T1  - RHabdomyolysis in fatal arsenic trioxide poisoning
AU  - Sanz P, Corbella J, Nogué S, Munné P, Rodriguez-Pazos M
Y1  - 1989/12/15
N1  - 10.1001/jama.1989.03430230043020
JO  - JAMA
SP  - 3271
EP  - 3271
VL  - 262
IS  - 23
N2  - To the Editor. — 
    We report a case of fatal arsenic poisoning with acute renal failure, circulatory collapse, and severe rhabdomyolysis.Report of Case.— 
    A 23-year-old man came to our hospital 1 hour after voluntary ingestion of 20 g of arsenic trioxide. On admission he was asymptomatic. He was treated with ipecac syrup, activated charcoal, and dimercaprol (3 mg/kg intramuscularly every 4 hours).Within 8 hours, arterial hypotension (95/50 mm Hg) and anuria ensued. Plasma expanders were perfused and a progressive rise of the central venous pressure, without the reestablishment of diuresis, was observed. Nine hours later, when the creatinine level was 300 μmol/L and the creatine phosphokinase level 1223 U/L, it was decided to carry out hemodialysis followed by a dopamine infusion due to the progressive hypotension.Evolution was characterized by refractory shock, the increase of rhabdomyolysis (creatine phosphokinase level, 31 350 U/L), hepatic dysfunction (aspartate aminotransferase level, 550
SN  - 0098-7484
M3  - doi: 10.1001/jama.1989.03430230043020
UR  - http://dx.doi.org/10.1001/jama.1989.03430230043020
ER  -