TY - JOUR T1 - MEta-analysis of empirical long-term antiarrhythmic therapy after myocardial infarction AU - Hine LK, Laird NM, Hewitt P, Chalmers TC Y1 - 1989/12/01 N1 - 10.1001/jama.1989.03430210079035 JO - JAMA SP - 3037 EP - 3040 VL - 262 IS - 21 N2 - SUDDEN cardiac death remains a major cause of mortality and a significant public health concern. At least 40% of sudden deaths occur in people with clinically overt heart disease, and among patients with coronary heart disease, the risk of sudden death is relatively greater for those patients who have had a myocardial infarction (MI) than for those who have not.1 Approximately 50% of MI-related deaths are sudden and usually caused by ventricular arrhythmias.2,3 Although the majority of these deaths occur in the earliest phases of MI,4 the risk of mortality beyond 1 year after MI remains four to eight times greater than that for comparable patients who did not have an MI.5,6 Approximately 35% to 40% of deaths that occur late after MI will be caused by sudden death.7The presence of premature ventricular contractions (PVCs) after MI has been shown to be a risk SN - 0098-7484 M3 - doi: 10.1001/jama.1989.03430210079035 UR - http://dx.doi.org/10.1001/jama.1989.03430210079035 ER -