TY  - JOUR
T1  - INtravenous magnesium sulfate for the treatment of acute asthma in the emergency department
AU  - Skobeloff EM, Spivey WH, McNamara RM, Greenspon L
Y1  - 1989/09/01
N1  - 10.1001/jama.1989.03430090072036
JO  - JAMA
SP  - 1210
EP  - 1213
VL  - 262
IS  - 9
N2  - Conventional nebulized β-agonist therapy has met with disappointing results in an increasing number of moderate to severe asthmatics who may be characterized as "poor responders." Thirty-eight patients suffering from acute exacerbations of moderate to severe asthma were treated in an emergency department with an intravenous infusion of saline placebo or 1.2 g of magnesium sulfate after conventional β-agonist therapy failed to produce significant improvement in peak expiratory flow rate. Nineteen patients were randomized into each of two groups in a placebo-controlled, double-blind clinical trial. The treatment group demonstrated an increase in peak expiratory flow rate from 225 to 297 L/min as compared with 208 to 216 L/min seen in the placebo group. In addition, the number admitted vs discharged was significantly better for the treatment group (7 vs 12) than the placebo group (15 vs 4). Intravenous magnesium sulfate may represent a beneficial adjunct therapy in patients with moderate to severe asthma who show little improvement with β-agonists.(JAMA. 1989;262:1210-1213)
SN  - 0098-7484
M3  - doi: 10.1001/jama.1989.03430090072036
UR  - http://dx.doi.org/10.1001/jama.1989.03430090072036
ER  -