TY  - JOUR
T1  - LIthium for zidovudine-induced neutropenia in aids-reply
AU  - Herbert V, Jacobson JJ, Fong WW, Stopler TT
Y1  - 1989/08/11
N1  - 10.1001/jama.1989.03430060069026
JO  - JAMA
SP  - 776
EP  - 776
VL  - 262
IS  - 6
N2  - In Reply.— 
    Drs Nathwani and Green are correct that the toxic effects of lithium are a real danger because of the polyinfections and frequent diarrhea of patients with acquired immunodeficiency syndrome (AIDS). We start with 300 mg of lithium carbonate twice daily, and only occasionally have to raise it to three times daily. We monitor serum lithium levels twice weekly for the first few weeks and reduce the dose if any serum lithium level reaches 1.40 mmol/L or if the patient reports a hand tremor or any other sign1 of a toxic reaction to lithium. We strive for a serum level of 0.60 to 1.20 mmol/L (>1.50 mmol/L signals a toxic effect).1Our experience is that lithium does not exacerbate erythrocyte macrocytosis in AIDS. In that connection, we find negative balance for vitamin B12 and folate to be frequent in AIDS,2 often being indicators of generalized
SN  - 0098-7484
M3  - doi: 10.1001/jama.1989.03430060069026
UR  - http://dx.doi.org/10.1001/jama.1989.03430060069026
ER  -