TY  - JOUR
T1  - HLa and immune response
AU  - McCombs CC, Michalski JP
Y1  - 1989/08/11
N1  - 10.1001/jama.1989.03430060068021
JO  - JAMA
SP  - 774
EP  - 774
VL  - 262
IS  - 6
N2  - To the Editor.— 
    We read with interest the article by Weissman et al that reports an association of HLA-DR3, DR4, and DR7 with nonresponsiveness to recombinant hepatitis B vaccine.1 These same HLA-DR antigens have an increased prevalence of celiac disease, a disorder in which an immune response to dietary gliadin seems to underlie the intestinal damage. HLA-DR3 and DR7 have in common a frequent association with the allele DQ2. It now seems that the "primary" association with celiac disease may be that of HLA-DQ2.2-5 It would be interesting to see if the nonresponders with HLA-DR3 and DR7 in the study by Weissman et al also have HLA-DQ2.In the case of celiac disease, a collaborative study by the Ninth Histocompatibility Workshop found that in a group of patients with celiac disease who lacked either DR3 or DR7, some had DQ2 in the absence of DR3 or DR7, while
SN  - 0098-7484
M3  - doi: 10.1001/jama.1989.03430060068021
UR  - http://dx.doi.org/10.1001/jama.1989.03430060068021
ER  -