TY - JOUR T1 - THe pharmacologic approach to the critically iii patient AU - Wilson RF Y1 - 1989/02/17 N1 - 10.1001/jama.1989.03420070118046 JO - JAMA SP - 1068 EP - 1068 VL - 261 IS - 7 N2 - This is an extremely important and informative book for anyone involved in the care of critically ill or injured patients. Its 900 + pages contain virtually everything a physician would like to know about any drugs that might be used in an intensive care unit (ICU).Section I (183 pages) deals with pharmacokinetics, drug interactions, and the alterations in dosing and drug choices required with various types of organ failure. The chapters on pharmacokinetics and cardiovascular adreno-receptors are a bit complex, but then so is the subject.Section II (118 pages), dealing with resuscitation pharmacology, reviews the agents used for cardiopulmonary resuscitation, drugs for central nervous system protection, colloids vs crystalloids, anesthetic agents, blood and blood components, red blood cell substitutes, and thrombolytic therapy. I thought that the "Crystalloid-Colloid" chapter was a bit skimpy, and it did not mention the current work on hypertonic saline. In the "Anesthetic" section, I would SN - 0098-7484 M3 - doi: 10.1001/jama.1989.03420070118046 UR - http://dx.doi.org/10.1001/jama.1989.03420070118046 ER -