TY  - JOUR
T1  - CAuses of hyperketonemia-reply
AU  - Schade DS
Y1  - 1979/11/02
N1  - 10.1001/jama.1979.03300180012011
JO  - JAMA
SP  - 1968
EP  - 1968
VL  - 242
IS  - 18
N2  - In Reply.— 
    Dr Spencer is correct in that patients with ketonuria by the nitroprusside reaction may have ingested large quantities of isopropyl alcohol. Isopropyl alcohol is metabolized by alcohol dehydrogenase.1 A recent publication by Van de Graaf and Thompson2 indicates that isopropyl alcohol intoxication is not an uncommon clinical condition in a large community hospital. This cause of hyperketonemia should be added to the table in our article. Thus, isopropyl alcohol intoxication results in a positive nitroprusside reaction, a normal blood pH, and euglycemia; the treatment would be to remove isopropyl alcohol from the circulation. The fact that cyanide intoxication may also induce ketosis has been reported, but the mechanisms of this unusual event are less clear.
SN  - 0098-7484
M3  - doi: 10.1001/jama.1979.03300180012011
UR  - http://dx.doi.org/10.1001/jama.1979.03300180012011
ER  -