TY  - JOUR
T1  - IS calcitriol [1,25(oh)2d3] harmful to renal function?
Y1  - 1979/10/26
N1  - 10.1001/jama.1979.03300170021019
JO  - JAMA
SP  - 1875
EP  - 1876
VL  - 242
IS  - 17
N2  - IT HAS long been known that patients with advanced renal failure require large doses of vitamin D for the expression of its biological effects.1 The discovery by Fraser and Kodicek2 that the kidney is responsible for the production of the active metabolite of vitamin D, 1,25(OH)2D3, provided an explanation for the vitamin D-resistant state in patients with chronic uremia and implied that such patients have a deficiency of 1,25(OH)2D3. Indeed, Brumbaugh et al3 found that the blood levels of this metabolite in patients with chronic renal failure are low or undetectable.The successful chemical synthesis of calcitriol made this metabolite available for replacement therapy, and its clinical use has recently been approved for the treatment of patients receiving dialysis.Since a deficiency of 1,25(OH)2D3 is present in patients who have advanced renal failure but who as yet do
SN  - 0098-7484
M3  - doi: 10.1001/jama.1979.03300170021019
UR  - http://dx.doi.org/10.1001/jama.1979.03300170021019
ER  -