TY  - JOUR
T1  - CLinical application of measurement of angiotensin-converting enzyme level
AU  - Shultz T, Miller WC, Bedrossian CM
Y1  - 1979/08/03
N1  - 10.1001/jama.1979.03300050029021
JO  - JAMA
SP  - 439
EP  - 441
VL  - 242
IS  - 5
N2  - Assay of angiotensin-converting enzyme (ACE) in the sera of 69 patients demonstrated elevated levels in 19 of 22 (86%) of those with clinically active, biopsy-proved sarcoidosis. Patients with dormant sarcoidosis and generally those with various other disorders had normal levels. Elevated levels were also seen in six cases possibly representing sarcoid variants and in one case each of leprosy, carcinoma, tuberculosis, lymphomatoid granulomatosis, and immunoblastic sarcoma. Although ACE is sensitive to active sarcoidosis, the presence of false-positive findings limits its diagnostic usefulness to an adjunctive role; the assay should be combined with medical evaluation and tissue biopsy in selected cases.(JAMA 242:439-441, 1979)
SN  - 0098-7484
M3  - doi: 10.1001/jama.1979.03300050029021
UR  - http://dx.doi.org/10.1001/jama.1979.03300050029021
ER  -