TY  - JOUR
T1  - HIrsutism, obesity, and phenothiazine therapy
AU  - Wieland RG
Y1  - 1979/08/03
N1  - 10.1001/jama.1979.03300050012006
JO  - JAMA
SP  - 414
EP  - 414
VL  - 242
IS  - 5
N2  - To the Editor.— 
    The report of Phillips et al (241:920, 1979) suggested an association of hirsutism with long-term phenothiazine therapy. The authors mentioned that testosterone levels were either normal or slightly below normal limits, although no numbers were given. In addition, no indication of levels of sex steroid binding globulin or free testosterone is available in the article.The figures showed the patient to be clearly obese. Obesity has a well-known effect on decreasing sex steroid binding globulin, thus increasing free1,2 but not necessarily total testosterone levels. It is clear now that this effect is reversible with weight loss produced by either intestinal bypass3 or dietary techniques4; thus, obesity would seem the more noteworthy explanation for the patient's hirsutism.
SN  - 0098-7484
M3  - doi: 10.1001/jama.1979.03300050012006
UR  - http://dx.doi.org/10.1001/jama.1979.03300050012006
ER  -