TY - JOUR T1 - EVolution of language AU - Pease RW, Jr Y1 - 1979/08/03 N1 - 10.1001/jama.1979.03300050011003 JO - JAMA SP - 413 EP - 413 VL - 242 IS - 5 N2 - To the Editor.—  The editorial by Samuel Vaisrub, MD (241:830, 1979), concerning the word "multifactorial" overlooked two dictionaries in which the term is defined. The following definition appears in a Merriam-Webster publication1:mul•ti•fac•to•ri•al*-fak′tōrē[unk]l, -′tȯr- ormul•ti•fac•tor -¦fakt[unk](r) adj: having or involving a variety of elements <a multifactorial study>Entries in Merriam-Webster dictionaries are based on citational evidence. At present, the citation files contain more than 12 1/2 million examples of English word usage recorded on 3×5-in slips. The earliest record of the new sense of multifactorial in the files is dated 1965 from Dubois2: "The concept of multifactorial causation is in reality but an extension of the doctrine of specificity that brings scientific understanding a little nearer to the complexities of the real world."The word is also defined in a recent supplement to the Oxford English Dictionary1 under sense 1 of the combining form multi-, where SN - 0098-7484 M3 - doi: 10.1001/jama.1979.03300050011003 UR - http://dx.doi.org/10.1001/jama.1979.03300050011003 ER -