TY  - JOUR
T1  - THrombophlebitis in systemic lupus erythematosus
AU  - Angles-Cano EE, Clauvel JP, Sultan YY
Y1  - 1979/06/29
N1  - 10.1001/jama.1979.03290520013012
JO  - JAMA
SP  - 2785
EP  - 2786
VL  - 241
IS  - 26
N2  - To the Editor.— 
    We read the report by Peck et al (240:1728, 1978) on thrombophlebitis in systemic lupus erythematosus (SLE), and we wish to comment on their assertions. We have recently done a prospective study searching for factors predisposing to thrombosis in patients with SLE (unpublished data), and we have reported thrombotic accidents in five of 28 patients. Four of these patients had arterial thrombosis, and only one had thrombophlebitis. The patients were tested for platelet function and coagulation, and fibrinolytic studies, including factor VIII complex activities1 and fibrinolytic activity2 of blood after venous stasis, were also carried out. Two major abnormalities were found: (1) an increase activity of the factor VIII complex in the absence of steroid therapy (VIII: C, 1.63 units/mL; VIII R: Ag, 1.86 units/mL; VIII R: Wf, 2.11 units/mL, mean values) and (2) an absence of plasminogen activator activity. It is possible that both abnormalities
SN  - 0098-7484
M3  - doi: 10.1001/jama.1979.03290520013012
UR  - http://dx.doi.org/10.1001/jama.1979.03290520013012
ER  -