TY  - JOUR
T1  - TReatment of hereditary angioedema
AU  - Kumar CM
Y1  - 1979/04/20
N1  - 10.1001/jama.1979.03290420011007
JO  - JAMA
SP  - 1683
EP  - 1684
VL  - 241
IS  - 16
N2  - To the Editor.— 
    In his letter "Hereditary Angioedema" (240:2155, 1978), Dr Reimann does not mention the use of androgenic steroids for prophylaxis of attacks. Methyltestosterone was first effectively used by Spaulding1 in 1960. This was followed by reports of effectiveness of less virilizing analogues, fluoxymesterone, oxymetholone,2 and danazol.3 The latter is a synthetic androgen derivative with mild masculanizing effects4 and is currently the drug of choice for prophylactic management of hereditary angioedema.5 It is not only highly effective in preventing attacks but has been shown to raise Cl esterase inhibitor function, as well as its levels and that of C4, often to within normal range.
SN  - 0098-7484
M3  - doi: 10.1001/jama.1979.03290420011007
UR  - http://dx.doi.org/10.1001/jama.1979.03290420011007
ER  -