TY  - JOUR
T1  - Antenatal diagnosis: What is 'standard?'
Y1  - 1979/04/20
N1  - 10.1001/jama.1979.03290420004002
JO  - JAMA
SP  - 1666
EP  - 1675
VL  - 241
IS  - 16
N2  - Prenatal diagnosis of birth defects by amniocentesis has increased threefold to ninefold in the last two years.Intrapartum electronic fetal monitoring, introduced into clinical obstetrics in 1969, was used in a whopping 70% of all births in 1978.Analysis of fetal lipids in amnionic fluid to determine fetal lung maturity is now routine in the management of premature or difficult births.To detect neural tube defects, the United Kingdom has instituted a successful program of screening maternal serum for increased α-fetoprotein (α-fp) levels, sparking enthusiasm for a similar effort in the United States.Use of fetoscopy for direct sampling of fetal blood has raised hopes for antenatal detection of hemoglobinopathies.Developments like these came in for intense discussion at a recent consensus development conference on antenatal diagnosis sponsored by the National Institutes of Health's (NIH) Office of Medical Applications of Research. Using three preliminary draft
SN  - 0098-7484
M3  - doi: 10.1001/jama.1979.03290420004002
UR  - http://dx.doi.org/10.1001/jama.1979.03290420004002
ER  -